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MYP_028685
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Basic Information
8
Anticancer
Antimicrobial
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
not Standard
2 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
YX
Physicochemical Analysis
0.00 Da
0.00
0.00
0.00
0.00
0.00
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0120105 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
ambiguous/non-standard residue notation [Modified]
None
None
X=Cα -dialkylated glycine (Aaa2,R )
Bio-Activity Profile
Antimicrobial Anticancer
HeLa
10;8.2;36.1 %
MTT assay
PaperTumor-cell-targeted methionine-enkephalin analogues containing unnatural amino acids: design, synthesis, and in vitro antitumor activity. J Med Chem. 2006 Jun 1;49(11):3136-42. doi: 10.1021/jm051026+. PMID: 16722632. PMID16722632 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16722632/
RECORD: Rec_0121552 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
ambiguous/non-standard residue notation [Modified]
None
None
X=Cα -dialkylated glycine (Aaa2,S )
Bio-Activity Profile
Antimicrobial Anticancer
10.5;21.9;11.8;17.9 %
MTT assay
PaperTumor-cell-targeted methionine-enkephalin analogues containing unnatural amino acids: design, synthesis, and in vitro antitumor activity. J Med Chem. 2006 Jun 1;49(11):3136-42. doi: 10.1021/jm051026+. PMID: 16722632. PMID16722632 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16722632/
RECORD: Rec_0122809 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
ambiguous/non-standard residue notation [Modified]
None
None
X=Cα -dialkylated glycine (Aaa2,R )
Bio-Activity Profile
Antimicrobial Anticancer
HeLa
7.5;6.1;3.1;14.8 %
MTT assay
PaperTumor-cell-targeted methionine-enkephalin analogues containing unnatural amino acids: design, synthesis, and in vitro antitumor activity. J Med Chem. 2006 Jun 1;49(11):3136-42. doi: 10.1021/jm051026+. PMID: 16722632. PMID16722632 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16722632/
RECORD: Rec_0135411 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
ambiguous/non-standard residue notation [Modified]
None
None
X=Cαα -dialkylated glycine (Aaa1 )
Bio-Activity Profile
Antimicrobial Anticancer
MCF-7
2.4;7.5 %
MTT assay
PaperTumor-cell-targeted methionine-enkephalin analogues containing unnatural amino acids: design, synthesis, and in vitro antitumor activity. J Med Chem. 2006 Jun 1;49(11):3136-42. doi: 10.1021/jm051026+. PMID: 16722632. PMID16722632 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16722632/
RECORD: Rec_0140726 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
ambiguous/non-standard residue notation [Modified]
None
None
X=Cα -dialkylated glycine (Aaa2,S )
Bio-Activity Profile
Antimicrobial Anticancer
12.9;16.5;28.1;58.2 %
MTT assay
PaperTumor-cell-targeted methionine-enkephalin analogues containing unnatural amino acids: design, synthesis, and in vitro antitumor activity. J Med Chem. 2006 Jun 1;49(11):3136-42. doi: 10.1021/jm051026+. PMID: 16722632. PMID16722632 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16722632/
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