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MYP_028685
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Basic Information
8
Anticancer
Antimicrobial
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
not Standard
2 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
YX
Physicochemical Analysis
0.00 Da
0.00
0.00
0.00
0.00
0.00
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0282144 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
ambiguous/non-standard residue notation [Modified]
None
None
X=Cαα -dialkylated glycine (Aaa1 )
Bio-Activity Profile
Antimicrobial Anticancer
HBL
6.5;14;7.5;14 %
MTT assay
PaperTumor-cell-targeted methionine-enkephalin analogues containing unnatural amino acids: design, synthesis, and in vitro antitumor activity. J Med Chem. 2006 Jun 1;49(11):3136-42. doi: 10.1021/jm051026+. PMID: 16722632. PMID16722632 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16722632/
RECORD: Rec_0283196 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
ambiguous/non-standard residue notation [Modified]
None
None
X=Cαα -dialkylated glycine (Aaa1 )
Bio-Activity Profile
Antimicrobial Anticancer
Caco-2
22.2;21.4;17.5;16 %
MTT assay
PaperTumor-cell-targeted methionine-enkephalin analogues containing unnatural amino acids: design, synthesis, and in vitro antitumor activity. J Med Chem. 2006 Jun 1;49(11):3136-42. doi: 10.1021/jm051026+. PMID: 16722632. PMID16722632 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16722632/
RECORD: Rec_0303477 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
ambiguous/non-standard residue notation [Modified]
None
None
X=Cαα -dialkylated glycine (Aaa1 )
Bio-Activity Profile
Antimicrobial Anticancer
HEp-2
2.7;2;18.8;26.7 %
MTT assay
PaperTumor-cell-targeted methionine-enkephalin analogues containing unnatural amino acids: design, synthesis, and in vitro antitumor activity. J Med Chem. 2006 Jun 1;49(11):3136-42. doi: 10.1021/jm051026+. PMID: 16722632. PMID16722632 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16722632/
RECORD: Rec_0304728 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
ambiguous/non-standard residue notation [Modified]
None
None
X=Cα -dialkylated glycine (Aaa2,R )
Bio-Activity Profile
Antimicrobial Anticancer
10.7;10;9.4;18.7 %
MTT assay
PaperTumor-cell-targeted methionine-enkephalin analogues containing unnatural amino acids: design, synthesis, and in vitro antitumor activity. J Med Chem. 2006 Jun 1;49(11):3136-42. doi: 10.1021/jm051026+. PMID: 16722632. PMID16722632 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16722632/
RECORD: Rec_0305294 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
ambiguous/non-standard residue notation [Modified]
None
None
X=Cαα -dialkylated glycine (Aaa1 )
Bio-Activity Profile
Antimicrobial Anticancer
10.5;21.9;11.8;17.9 %
MTT assay
PaperTumor-cell-targeted methionine-enkephalin analogues containing unnatural amino acids: design, synthesis, and in vitro antitumor activity. J Med Chem. 2006 Jun 1;49(11):3136-42. doi: 10.1021/jm051026+. PMID: 16722632. PMID16722632 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16722632/
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