Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length456 amino acids

Chemical FormulaC2262H3612N600O640S17

DescriptionStandard

        TNPGFMVRITQAGLDYARVQGIAILEKELANVKLPDISGDSRIKVLGKVRYEISRLDLTGFRLPNSQISLVPNVGLQVSISNAYTKVKGNWRVKLRFIRDHGSFEVTVENTNMNINLKLGNDASGKPTVDTSGCSIHISKVRVRFSGRLGWLYNLFHKVIESKLRKILEGKVCDIVAKSVRSNLQPYIQTLPVTAKIDTIVGLDYSLVAPPTATAQSLDVAMKGEFFSMANRSAVPFAPLALTLPPDHDRMVYFGASSYFFNTASFAYHEAGALVFEITDSMITKGTSFHLDTTTFSAFVPQLEEIYPAMGMKFRLYAPSAPLLSIGPGGLLLKPVVDMQAYAILPNSSLAPLFLISLVSNISAVINVESCHITGNLKMGRMKLSLKHSDVGTFQVESLESIMNFLASSILLPRINDRLGQGFPLPMPKGMQLSNIIVQFHPNILLLGGDIHSQPQ
    

Molecular Weight49997.62 Da

Isoelectric Point (pI)9.37

Net Charge (pH 7.0)10.27

Net Charge (pH 7.4) 9.44

Charge Density (pH 7.0) 0.0225

GRAVY Index0.14

Hydrophobic Moment 0.71

Boman Index0.14

Instability Index36.51

Aliphatic Index 103.25

Aromaticity 0.0811

Extinction Coeff. Reduced 28880.00

Extinction Coeff. Oxidized 29005.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0294995 VERIFIED: NO

Provenance & Taxonomy

OrganismJacana jacana (Wattled jacana) [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria