Peptide Database

Peptide NameHelaTx1

Function Ontology

Membrane / Ion-channel modulation ▸ Ion channel modulation

Standard StatusStandard

Sequence Length25 amino acids

Chemical FormulaC113H197N45O36S5

DescriptionStandard

        SCKKECSGSRRTKKCMQKCNREHGH
    

Molecular Weight2922.38 Da

Isoelectric Point (pI)9.70

Net Charge (pH 7.0)5.60

Net Charge (pH 7.4) 5.22

Charge Density (pH 7.0) 0.2238

GRAVY Index-1.82

Hydrophobic Moment 0.63

Boman Index-0.67

Instability Index73.69

Aliphatic Index 0.00

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 250.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1376.58

LogP -20.64

H-bond Donors 54.0

H-bond Acceptors 49.0

Rotatable Bonds 107.0

Heavy Atoms 199.0

Ring Count 2.0

Amide Bonds 26.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0363694 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

FamilyGtoPdb peptide ligand

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfidereported in GtoPdb PTM annotation

Other ModsDisulphide bond formation between cysteine residues at positions 2 and 19, and 7 and 15. C terminal histidine residue is histidine amide.

Bio-Activity Profile

Function

Ion channel modulation

TargetKv1.1 (Human)

Activity9900 nM

MethodEC50