Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length507 amino acids

Chemical FormulaC2577H4013N647O740S17

DescriptionStandard

        MCTKTIPVLWGCFLLWHLCLSSSQTIYPGIKARITQRALDYGVQAGMEIIERMLKEKNLPDLRGSESLEFLKVDYVNYNFSNIKIRAFSFPNTSLAFVPGVGIKALTNHGTANISTDWEFESPLFQDTGGADLFLSGVYFTGIIILTRNDFGHPTLKLQDCYAQVSHAHVSFSGELSVLYNSFAEPMEKPILKNLNEMLCPIIASEVKALNANLSTLEVLTKIDNYTLLDYSLISSPEITENYLDLNLKGVFYPLENLADPPFSPVPFVLPERSNSMLYIGITKYFFKSASFAYFTAGAFNVTLSTKEISNHFVQNSQGLGNVLSRIAEIYILSQPFMVRIMATEPPIINLQPGNFTLDIPASIMMLTQPKNSTVETIVSMDFVASTSVGLVILGQRLVCSLSLNRFRLALPESNRSNIEVLRFENILSSILHFGVLPLANAKLQQGFPLPNPHKISFVNSDIEVLEGFLLISTDLKYETSSKQQPSFHGWEGLNLISGQWRGKSAP
    

Molecular Weight56443.42 Da

Isoelectric Point (pI)5.78

Net Charge (pH 7.0)-6.72

Net Charge (pH 7.4) -7.59

Charge Density (pH 7.0) -0.0132

GRAVY Index0.12

Hydrophobic Moment 0.71

Boman Index0.16

Instability Index39.82

Aliphatic Index 101.91

Aromaticity 0.1045

Extinction Coeff. Reduced 51340.00

Extinction Coeff. Oxidized 51715.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0353084 VERIFIED: NO

Provenance & Taxonomy

OrganismMacaca nemestrina [Animal]

FamilyBPI

Tax ID9545

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence