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MYP_028596
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Basic Information
Cathelicidin antimicrobial peptide (18 kDa cationic antimicrobial protein) (CAP-18) (hCAP-18) [Cleaved into: Antibacterial peptide FALL-39 (FALL-39 peptide antibiotic); Antibacterial peptide LL-37; Antibacterial peptide KR-20; Antibacterial peptide LL-23; Antibacterial peptide LL-29; Antibacterial peptide KS-30; Antibacterial peptide RK-31; Antibacterial peptide FF-33]
Antimicrobial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive ▸ Anti-Staphylococcus aureus
Antimicrobial ▸ Anti-biofilm ▸ Biofilm inhibition
Antimicrobial ▸ Antibiotic activity
Antimicrobial ▸ Antifungal
Antimicrobial ▸ Antifungal ▸ Anti-Candida
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
170 amino acids
C850H1393N245O250S8
Standard
Sequence
MKTQRDGHSLGRWSLVLLLLGLVMPLAIIAQVLSYKEAVLRAIDGINQRSSDANLYRLLDLDPRPTMDGDPDTPKPVSFTVKETVCPRTTQQSPEDCDFKKDGLVKRCMGTVTLNQARGSFDISCDKDNKRFALLGDFFRKSKEKIGKEFKRIVQRIKDFLRNLVPRTES
Physicochemical Analysis
19301.16 Da
9.48
7.57
7.19
0.0445
-0.44
0.97
-0.14
37.59
87.12
0.0647
8480.00
8730.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
8068.35
-88.26
285.0
267.0
659.0
1353.0
22.0
181.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0012529 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Cathelicidin
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibiotic Anti-MRSA Antibiofilm Antifungal Anti-Candida Anti-Gram-negative Anti-Gram-positive Hemolytic Synergistic peptide
P. syringae (Gram-negative)
PaperThe status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) PMID7529412;7615076;7890387;8946956;8681941;11238224;15489334;9736536;10417311;11389039;14978112;15778390;21463582;22879591;34708076;16637646;18818205;22185690;23406372;29087182;29133814;29317506;32753597;33060695;35061360 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/7529412/
RECORD: Rec_0027047 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Cathelicidin
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibiotic Anti-MRSA Antibiofilm Antifungal Anti-Candida Anti-Gram-negative Anti-Gram-positive Hemolytic Synergistic peptide
S. epidermidis (Gram-positive)
PaperThe status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) PMID7529412;7615076;7890387;8946956;8681941;11238224;15489334;9736536;10417311;11389039;14978112;15778390;21463582;22879591;34708076;16637646;18818205;22185690;23406372;29087182;29133814;29317506;32753597;33060695;35061360 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/7529412/
RECORD: Rec_0037593 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Cathelicidin
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibiotic Anti-MRSA Antibiofilm Antifungal Anti-Candida Anti-Gram-negative Anti-Gram-positive Hemolytic Synergistic peptide
Candida albicans
PaperThe status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) PMID7529412;7615076;7890387;8946956;8681941;11238224;15489334;9736536;10417311;11389039;14978112;15778390;21463582;22879591;34708076;16637646;18818205;22185690;23406372;29087182;29133814;29317506;32753597;33060695;35061360 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/7529412/
RECORD: Rec_0046269 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Cathelicidin
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibiotic Anti-MRSA Antibiofilm Antifungal Anti-Candida Anti-Gram-negative Anti-Gram-positive Hemolytic Synergistic peptide
B. megaterium
PaperThe status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) PMID7529412;7615076;7890387;8946956;8681941;11238224;15489334;9736536;10417311;11389039;14978112;15778390;21463582;22879591;34708076;16637646;18818205;22185690;23406372;29087182;29133814;29317506;32753597;33060695;35061360 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/7529412/
RECORD: Rec_0080190 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Cathelicidin
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibiotic Anti-MRSA Antibiofilm Antifungal Anti-Candida Anti-Gram-negative Anti-Gram-positive Hemolytic Synergistic peptide
Escherichia coli (Gram-negative)
PaperThe status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) PMID7529412;7615076;7890387;8946956;8681941;11238224;15489334;9736536;10417311;11389039;14978112;15778390;21463582;22879591;34708076;16637646;18818205;22185690;23406372;29087182;29133814;29317506;32753597;33060695;35061360 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/7529412/
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