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MYP_028309
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Basic Information
L-amino acid oxidase (LAO) (MipLAAO1) (EC 1.4.3.2)
Antimicrobial
Antimicrobial ▸ Antibiotic activity
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Enzyme / Catalytic activity ▸ Oxidoreductase
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Venom / Toxin ▸ General toxin ▸ Toxin
Standard
501 amino acids
C2587H4002N694O738S15
Standard
Sequence
MNVFFMFSLVFLAAFGSCADDTRPLGECFREADYEEFLEIARNGLKKTSNPKHVVVVGAGMSGLSAAYVLAKAGHKVTLLEASEGVGGRVKTYRNKQEGWYINLGPMRLPERHRIVREYIRKFHLPLSEFVQENENTWYYIKNIRKRVSEVKKNPDLFEYPVNPSEKGKSASQLYQESLEKVIDELKRTNCNHILNKYDTYSTKEYLIKEGNLSPGAVDMIGDLLNEDSSFYLSFIESLKSDDIFSYEKRFDEIVGGFDQLPISMYQAIAEMVHLNAQVIKIQHNAKKVIVTYQTPAKTLPSVTADYVIVCSTSRAARHIRFQPPLPTNKARALRSIHYRSAIKIFLTCTKRFWEADGIHGGKSTTDLPSRFIYYFNQNFTNGIGVIMAYVLADDAKFFQPHDLKTNADIVINDLSLIHQLPKEEIQALCRPSWIQKWSLDKYAMGSITSFTPYQFLDYFEIAAAPVGRIHFAGEYTAKHHGWIDSTIKSGLRAARDVNRA
Physicochemical Analysis
57114.63 Da
8.81
7.80
6.58
0.0156
-0.30
0.95
0.01
36.96
85.09
0.1158
70250.00
70625.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0269351 VERIFIED: NO
Provenance & Taxonomy
Micrurus mipartitus [Animal]
Flavin monoamine oxidase; FIG1 subfamily
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibiotic Antiparasitic Oxidoreductase Cytolytic Toxin Hemolytic
-
PMID29900074;31129208 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29900074/
RECORD: Rec_0433067 VERIFIED: YES
Provenance & Taxonomy
Micrurus mipartitus [Animal]
L-amino acid oxidase
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Bactericidal Oxidoreductase
Staphylococcus aureus
2 μg/mL
MIC
PaperMipLAAO, a new L-amino acid oxidase from the redtail coral snake Micrurus mipartitus PMID29900074
RECORD: Rec_0433075 VERIFIED: YES
Provenance & Taxonomy
Micrurus mipartitus [Animal]
Structure & Mods
Bio-Activity Profile
Antimicrobial Antibacterial Bactericidal
Staphylococcus aureus ATCC 25923
2 µg/mL
MIC (broth microdilution)
PaperMipLAAO: A novel L-amino acid oxidase from Micrurus mipartitus snake venom with antibacterial activity PMID29900074
RECORD: Rec_0433076 VERIFIED: YES
Provenance & Taxonomy
Micrurus mipartitus [Animal]
Structure & Mods
Bio-Activity Profile
Pro-apoptotic Cytotoxic Anticancer
Jurkat T-ALL cells
Apoptosis assay (fluorescence microscopy and flow cytometry)
PaperMipLAAO1 induces apoptosis in Jurkat T-ALL cells PMID31129208