Peptide Database

Peptide NamePENK(238-259)

Function Ontology

Neurological / Signaling ▸ Analgesic/opioid activity ▸ Analgesic

Neurological / Signaling ▸ Analgesic/opioid activity ▸ Opioid

Neurological / Signaling ▸ Neuromodulation

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide

Standard StatusStandard

Sequence Length22 amino acids

Chemical FormulaC108H161N23O44

DescriptionStandard

        FAESLPSDEEAESYSKEVPEIE
    

Molecular Weight2485.56 Da

Isoelectric Point (pI)4.05

Net Charge (pH 7.0)-7.22

Net Charge (pH 7.4) -7.44

Charge Density (pH 7.0) -0.3280

GRAVY Index-0.94

Hydrophobic Moment 0.48

Boman Index-0.08

Instability Index104.76

Aliphatic Index 57.73

Aromaticity 0.0909

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1082.41

LogP -10.80

H-bond Donors 35.0

H-bond Acceptors 37.0

Rotatable Bonds 81.0

Heavy Atoms 175.0

Ring Count 4.0

Amide Bonds 21.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0260305 VERIFIED: NO

Provenance & Taxonomy

OrganismMesocricetus auratus [Animal]

FamilyOpioid

Tax ID10036

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Opioid Analgesic Neuromodulator

RECORD: Rec_0292940 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Neuropeptide

Paper数据库级溯源文献：Wang Y, Wang M, Yin S, et al. NeuroPep: a comprehensive resource of neuropeptides. Database (Oxford). 2015:bav038. PMID 25931458; Bin Y, Zhang W, Tang W, et al. Prediction of Neuropeptides from Sequence Information Using Ensemble Classifier and Hybrid Features. J Proteome Res. 2020;19(9):3732-3740. PMID 32786686. PMID25931458;32786686 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25931458/