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MYP_028248
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Basic Information
Entry 6
Antimicrobial
Antiviral
Antiviral ▸ Anti-Flavivirus ▸ Anti-Dengue virus
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition
Standard
8 amino acids
C31H59N13O10
Standard
Sequence
GKRKSGAA
Physicochemical Analysis
773.88 Da
11.17
2.76
2.55
0.3448
-1.29
0.27
-0.44
28.27
25.00
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
401.19
-6.39
15.0
13.0
28.0
54.0
0.0
7.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0025886 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
No specific N-terminal
No specific C-terminal
The N-terminal and C-terminal cyclized by a amide bond.
Bio-Activity Profile
Antiviral Anti-DENV Replication inhibition
Dengue virus 2(DENV2)
57.4 μM
IC50
Mammalian: 30 h; Yeast: >20 h; E. coli: >10 h
PaperDiscovery of novel cyclic peptide inhibitors of dengue virus NS2B-NS3 protease with antiviral activity. | Takagi Y, Matsui K, Nobori H, Maeda H, Sato A, Kurosu T, Orba Y, Sawa H, Hattori K, Higashino K, Numata Y, Yoshida Y. | Bioorg Med Chem Lett. 2017 Aug 1;27(15):3586-3590. | DOI:10.1016/j.bmcl.2017.05.027 | PMID:28539222 PMID28539222 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28539222/
RECORD: Rec_0194386 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
not reported
not reported
The N-terminal and C-terminal cyclized by a amide bond
Bio-Activity Profile
Antimicrobial Antiviral
PaperPubMed PMID: 28539222 PMID28539222 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28539222/
RECORD: Rec_0198652 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
not reported
not reported
The N-terminal and C-terminal cyclized by a amide bond
Bio-Activity Profile
Antimicrobial Antiviral
dengue virus 2(DENV2):inhibition of the activity of NS2B-NS3 protease
57.4 μM
IC50
PaperPubMed PMID: 28539222 PMID28539222 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28539222/