Peptide Database

Peptide NameBactericidal permeability-increasing protein

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length473 amino acids

Chemical FormulaC2322H3649N591O666S22

DescriptionStandard

        VVHMTCSCLTTLILGIELCAENPGVQVILTDKGLQYGKHLGAGWIQEKLPLVTFPDINGRLLGSIYYTLSGVTITKCDLPEPSVEFYQEVNGVKTSVSGLSVAVTGRWTTQFGLIHDGGSFNLALFNMDVTSEVALGKDDGGHLSVTSVHCNTRLQDVNMQFYGGASWMFNPLVDYFKGHIKSKIEAAICPAVDEYIANLEYHLQAMKVSFDVDENVTFDLPLISIPIVNASSMNLGLKGEFYSVRPRIDPPFEAQPFTVEKQPGYMLSVGLSEFTLNSASFALHSAGLLQTIITDSMIPPNIPVHLNTSWMGPYVPQLPKMFPGLLMVLQIYAREVPMFSFQSGVVKLPIEGAVKAFAIQPNGTQIPLFKLHVSASYSNRFLSGVTAGRMLLSNSFTLALASSEVGTFQTGALERAMKVGLSLGFVRLNAELGKGAVLPRMKNAQLVNTVLGMEKGFVAIASDVQVLLAGVN
    

Molecular Weight51205.80 Da

Isoelectric Point (pI)5.95

Net Charge (pH 7.0)-5.41

Net Charge (pH 7.4) -6.31

Charge Density (pH 7.0) -0.0114

GRAVY Index0.27

Hydrophobic Moment 0.57

Boman Index0.21

Instability Index31.53

Aliphatic Index 101.14

Aromaticity 0.0888

Extinction Coeff. Reduced 41370.00

Extinction Coeff. Oxidized 41745.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0145078 VERIFIED: NO

Provenance & Taxonomy

OrganismGasterosteus aculeatus [Animal]

FamilyBPI/LBP

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic Non-ribosomal

TargetGram-negative bacteria

MethodQualitative functional evidence