Peptide Database

Peptide NameM-theraphotoxin-Gr1a (M-TRTX-Gr1a; GsMTx-4)

Function Ontology

Annotation / Sequence feature ▸ Nuclear export signal

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity

Membrane / Ion-channel modulation ▸ Ion channel inhibition

Venom / Toxin ▸ General toxin ▸ huwentoxin-1 family

Venom / Toxin ▸ General toxin ▸ Toxin

Venom / Toxin ▸ Toxin

Standard StatusStandard

Sequence Length34 amino acids

Chemical FormulaC185H278N48O46S6

DescriptionStandard

        GCLEFWWKCNPNDDKCCRPKLKCSKLFKLCNFSF
    

Molecular Weight4102.87 Da

Isoelectric Point (pI)8.89

Net Charge (pH 7.0)3.70

Net Charge (pH 7.4) 3.40

Charge Density (pH 7.0) 0.1088

GRAVY Index-0.43

Hydrophobic Moment 0.46

Boman Index-0.11

Instability Index-1.14

Aliphatic Index 45.88

Aromaticity 0.1765

Extinction Coeff. Reduced 11000.00

Extinction Coeff. Oxidized 11375.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1537.27

LogP -11.32

H-bond Donors 58.0

H-bond Acceptors 56.0

Rotatable Bonds 134.0

Heavy Atoms 285.0

Ring Count 10.0

Amide Bonds 36.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0424273 VERIFIED: YES

Provenance & Taxonomy

OrganismGrammostola rosea [Animal]

Structure & Mods

ConfigSingle-chain peptide backbone represented as a linear sequence entry [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative

TargetSalmonella typhimurium

Activity32.64 μM

MethodMIC

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