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MYP_028205
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Basic Information
M-theraphotoxin-Gr1a (M-TRTX-Gr1a; GsMTx-4)
Annotation / Sequence feature ▸ Nuclear export signal
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Membrane / Ion-channel modulation ▸ Ion channel inhibition
Venom / Toxin ▸ General toxin ▸ huwentoxin-1 family
Venom / Toxin ▸ General toxin ▸ Toxin
Venom / Toxin ▸ Toxin
Standard
34 amino acids
C185H278N48O46S6
Standard
Sequence
GCLEFWWKCNPNDDKCCRPKLKCSKLFKLCNFSF
Physicochemical Analysis
4102.87 Da
8.89
3.70
3.40
0.1088
-0.43
0.46
-0.11
-1.14
45.88
0.1765
11000.00
11375.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1537.27
-11.32
58.0
56.0
134.0
285.0
10.0
36.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0198960 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 0.0%, E 26.5%, T 38.2%, C 35.3% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antibacterial Antimicrobial
PaperCAMP: Collection of sequences and structures of antimicrobial peptides PMID24265220 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24265220/
RECORD: Rec_0227248 VERIFIED: YES
Provenance & Taxonomy
Grammostola rosea [Animal]
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli
8-16 μM
MIC
PMID16376854 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16376854/
RECORD: Rec_0251324 VERIFIED: YES
Provenance & Taxonomy
Grammostola rosea [Animal]
huwentoxin-1 family
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
2-17; 9-23; 16-30
Bio-Activity Profile
Toxin Venom huwentoxin-1 family Antibacterial Ion channel inhibitor Pathogenesis-associated Host defense
PaperPDB 1LU8 structural record; NMR; chain A; residues 1-34
RECORD: Rec_0305842 VERIFIED: YES
Provenance & Taxonomy
Grammostola rosea [Animal]
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
2-17, 9-23, 16-30
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Pseudomonas aeruginosa
8-16 μM
MIC
PMID12082099;10779316;163768 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12082099/
RECORD: Rec_0334306 VERIFIED: YES
Provenance & Taxonomy
Grammostola rosea [Animal]
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
2-17, 9-23, 16-30
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus
2-4 μM
MIC
PMID12082099;10779316;163768 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12082099/
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