Peptide Database

Peptide NameIL-37

Function Ontology

Immunology ▸ Immune modulation ▸ Immunomodulatory activity

Neurological / Signaling ▸ Receptor modulation ▸ Agonist

Neurological / Signaling ▸ Signaling peptide

Standard StatusStandard

Sequence Length173 amino acids

Chemical FormulaC861H1350N234O252S9

DescriptionStandard

        VHTSPKVKNLNPKKFSIHDQDHKVLVLDSGNLIAVPDKNYIRPEIFFALASSLSSASAEKGSPILLGVSKGEFCLYCDKDKGQSHPSLQLKKEKLMKLAAQKESARRPFIFYRAQVGSWNMLESAAHPGWFICTSCNCNEPVGVTDKFENRKHIEFSFQPVCKAEMSPSEVSD
    

Molecular Weight19299.93 Da

Isoelectric Point (pI)8.71

Net Charge (pH 7.0)4.22

Net Charge (pH 7.4) 3.56

Charge Density (pH 7.0) 0.0244

GRAVY Index-0.38

Hydrophobic Moment 0.45

Boman Index-0.02

Instability Index54.57

Aliphatic Index 74.97

Aromaticity 0.0867

Extinction Coeff. Reduced 15470.00

Extinction Coeff. Oxidized 15845.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 7791.29

LogP -83.53

H-bond Donors 269.0

H-bond Acceptors 271.0

Rotatable Bonds 644.0

Heavy Atoms 1356.0

Ring Count 34.0

Amide Bonds 186.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0234487 VERIFIED: YES

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

FamilyGtoPdb endogenous peptide ligand

Tax ID9606

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Receptor agonist Immunomodulatory Signaling peptide

TargetInterleukin-18 receptor (Human); single Ig and TIR domain containing (Human)