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MYP_028134
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Basic Information
Casein beta [074-076], beta-Casokinin II
Cardiovascular ▸ Blood pressure regulation ▸ Antihypertensive
Enzyme modulation ▸ Enzyme inhibition
Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory
Enzyme modulation ▸ Enzyme inhibition ▸ Amylase inhibition ▸ Alpha-amylase inhibitory
Enzyme modulation ▸ Enzyme inhibition ▸ Glycosidase inhibition ▸ Alpha-glucosidase inhibitory
Hormonal / Endocrine ▸ Hormone peptide
Immunology ▸ Immune modulation ▸ Immunomodulatory activity
Immunology ▸ Inflammation modulation ▸ Anti-inflammatory
Membrane / Ion-channel modulation ▸ Calcium channel modulation ▸ Calcium channel inhibitor
Metabolic ▸ Glucose metabolism ▸ Antidiabetic
Metabolic ▸ Lipid metabolism ▸ Cholesterol-lowering
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Therapeutic / Biomedical activity ▸ Regenerative medicine ▸ Bone metabolism ▸ Osteoanabolic activity
Standard
3 amino acids
C16H27N3O4
Standard
Sequence
IPP
Physicochemical Analysis
325.40 Da
5.53
-0.24
-0.44
-0.0800
0.43
0.42
0.54
61.27
130.00
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
103.94
0.43
2.0
4.0
5.0
23.0
2.0
2.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0197712 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
ACE-inhibitory peptide
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antihypertensive
Spontaneously hypertensive rat (SHR)
7 mmHg
SBP decrease
PaperEngineering production of antihypertensive peptides in plants
RECORD: Rec_0220585 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
ACE-inhibitory peptide
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antihypertensive
PaperQSAR-aided in silico approach in evaluation of food proteins as precursors of ACE inhibitory peptides
RECORD: Rec_0238673 VERIFIED: YES
Provenance & Taxonomy
Secale cereale [Plant]; Triticum aestivum [Plant]
Bioactive peptides
4550, 4565
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
ACE inhibitory Antihypertensive
Angiotensin-converting enzyme
5 μM
IC50
PaperPubMed PMID 21985248 PMID21985248 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21985248/
RECORD: Rec_0264181 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 0.0%, E 0.0%, T 0.0%, C 100.0% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antihypertensive
PaperAHTPDB: a comprehensive platform for analysis and presentation of antihypertensive peptides PMID25392419 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25392419/
RECORD: Rec_0275765 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
kappa-Casein-derived
9913
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Osteoanabolic Bone-protective Osteoblast-proliferative
UMR-106 osteosarcoma cells
50 μM
Cell proliferation assay
PaperEffects of bioactive peptides isoleucine-proline-proline (IPP), valine-prolineproline (VPP) and leucine-lysine-proline (LKP) on gene expression of osteoblasts differentiated from human mesenchymal stem cells | Huttunen, M. et al. | DOI: 10.1017/S0007114507744434 PMID17466096 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17466096/
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