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MYP_028134
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Basic Information
Casein beta [074-076], beta-Casokinin II
Cardiovascular ▸ Blood pressure regulation ▸ Antihypertensive
Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory
Enzyme modulation ▸ Enzyme inhibition ▸ Amylase inhibition ▸ Alpha-amylase inhibitory
Enzyme modulation ▸ Enzyme inhibition ▸ Glycosidase inhibition ▸ Alpha-glucosidase inhibitory
Hormonal / Endocrine ▸ Hormone peptide
Immunology ▸ Immune modulation ▸ Immunomodulatory activity
Immunology ▸ Inflammation modulation ▸ Anti-inflammatory
Membrane / Ion-channel modulation ▸ Calcium channel modulation ▸ Calcium channel inhibitor
Metabolic ▸ Glucose metabolism ▸ Antidiabetic
Metabolic ▸ Lipid metabolism ▸ Cholesterol-lowering
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Other / Curated residual function label ▸ Generic enzyme inhibition annotation
Therapeutic / Biomedical activity ▸ Regenerative medicine ▸ Bone metabolism ▸ Osteoanabolic activity
Standard
3 amino acids
C16H27N3O4
Standard
Sequence
IPP
Physicochemical Analysis
325.40 Da
5.53
-0.24
-0.44
-0.0800
0.43
0.42
0.54
61.27
130.00
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
103.94
0.43
2.0
4.0
5.0
23.0
2.0
2.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0075031 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
kappa-Casein-derived
9913
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
ACE inhibitory Antihypertensive
Angiotensin-converting enzyme (ACE)
7.6 μM
IC50
PaperScreening milk-derived antihypertensive peptides using quantitative structure activity relationship (QSAR) modelling and in vitro/in vivo studies on their bioactivity | Jing, P. et al. | DOI: 10.1016/j.idairyj.2013.10.009 Evidence URLhttps://www.uniprot.org/uniprotkb/P02668/entry
RECORD: Rec_0079646 VERIFIED: YES
Provenance & Taxonomy
Oryza sativa [Plant]
4530
Structure & Mods
proteolytic peptide fragment [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antihypertensive ACE inhibitory
Spontaneously hypertensive rats (SHR)
PaperPMID 19619856 PMID19619856 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19619856/
RECORD: Rec_0083408 VERIFIED: NO
Provenance & Taxonomy
Homo sapiens [Animal]
ACE-inhibitory peptide
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antihypertensive
Spontaneously hypertensive rat (SHR)
15.1 mmHg
SBP decrease
PaperAntihypertensive Peptides Specific to Lactobacillus helveticus Fermented Milk
RECORD: Rec_0090493 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
proteolytic peptide fragment [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antihypertensive ACE inhibitory
Angiotensin-converting enzyme (ACE)
PaperNovel probiotic-fermented milk with angiotensin I-converting enzyme inhibitory peptides produced by Bifidobacterium bifidum MF 20/5 PMID24135669 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24135669/
RECORD: Rec_0091661 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
kappa-Casein-derived
9913
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Immunomodulatory Anti-inflammatory
3T3-F442A preadipocytes
PaperMilk-Derived Tripeptides IPP (Ile-Pro-Pro) and VPP (Val-Pro-Pro) Promote Adipocyte Differentiation and Inhibit Inflammation in 3T3-F442A Cells | Chakrabarti, S. et al. | DOI: 10.1371/journal.pone.0117492 Evidence URLhttps://www.uniprot.org/uniprotkb/P02668/entry
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