Peptide Database

Peptide NameUnnamed

Function Ontology

Neurological / Signaling ▸ Analgesic/opioid activity ▸ Analgesic

Neurological / Signaling ▸ Analgesic/opioid activity ▸ Opioid

Neurological / Signaling ▸ Neuromodulation

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide

Neurological / Signaling ▸ Pain modulation ▸ Pronociceptive activity

Regulatory peptide ▸ Biological modulation

Standard StatusStandard

Sequence Length70 amino acids

Chemical FormulaC332H544N88O111S6

DescriptionStandard

        ECSQDCATCSYRLARPTDLNPLACTLECEGKLPSLKTWETCKELLQLTKLELPPDATSALSKQEESHLLA
    

Molecular Weight7736.78 Da

Isoelectric Point (pI)4.78

Net Charge (pH 7.0)-4.12

Net Charge (pH 7.4) -4.45

Charge Density (pH 7.0) -0.0588

GRAVY Index-0.36

Hydrophobic Moment 0.58

Boman Index-0.06

Instability Index59.90

Aliphatic Index 86.57

Aromaticity 0.0286

Extinction Coeff. Reduced 6990.00

Extinction Coeff. Oxidized 7365.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 3191.52

LogP -34.20

H-bond Donors 114.0

H-bond Acceptors 114.0

Rotatable Bonds 256.0

Heavy Atoms 537.0

Ring Count 9.0

Amide Bonds 73.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0034102 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Neuropeptide

Paper数据库级溯源文献：Wang Y, Wang M, Yin S, et al. NeuroPep: a comprehensive resource of neuropeptides. Database (Oxford). 2015:bav038. PMID 25931458; Bin Y, Zhang W, Tang W, et al. Prediction of Neuropeptides from Sequence Information Using Ensemble Classifier and Hybrid Features. J Proteome Res. 2020;19(9):3732-3740. PMID 32786686. PMID25931458;32786686 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25931458/

RECORD: Rec_0262216 VERIFIED: YES

Provenance & Taxonomy

OrganismBos taurus [Animal]

FamilySynenkephalin

Tax ID9913

Structure & Mods

Configlinear peptide with reported disulfide constraint [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide2-24; 6-28; 9-41

Bio-Activity Profile

Function

Analgesic Pronociceptive Neuropeptide Neuromodulator Receptor modulation

Half-LifeMammalian: 1 hour; Yeast: 30 min; E. coli: >10 hour

RECORD: Rec_0394832 VERIFIED: NO

Provenance & Taxonomy

OrganismBos taurus [Animal]

FamilyOpioid

Tax ID9913

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Opioid Analgesic Neuromodulator