Peptide Database

Peptide NameSLAY-screened peptide P3580

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC100H146N28O33S

DescriptionStandard

        NYHQYPSFTTSSTKHVNSAM
    

Molecular Weight2300.46 Da

Isoelectric Point (pI)8.51

Net Charge (pH 7.0)0.93

Net Charge (pH 7.4) 0.62

Charge Density (pH 7.0) 0.0466

GRAVY Index-0.98

Hydrophobic Moment 0.34

Boman Index-0.07

Instability Index37.33

Aliphatic Index 19.50

Aromaticity 0.1500

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 2980.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1002.15

LogP -14.13

H-bond Donors 35.0

H-bond Acceptors 37.0

Rotatable Bonds 70.0

Heavy Atoms 162.0

Ring Count 6.0

Amide Bonds 22.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0305192 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/