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MYP_027968
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Basic Information
Cycloviolacin-O1 (Plant defensin)
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antiparasitic ▸ Anthelminthic
Antiparasitic ▸ Anthelminthic ▸ Nematicidal activity
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Insecticidal/Pest control ▸ Insecticidal activity
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
30 amino acids
C131H211N35O42S6
Standard
Sequence
GIPCAESCVYIPCTVTALLGCSCSNRVCYN
Physicochemical Analysis
3140.68 Da
5.96
-0.30
-0.59
-0.0100
0.75
0.36
0.24
31.05
87.67
0.0667
2980.00
3355.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1216.63
-14.98
48.0
48.0
94.0
214.0
4.0
31.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0382217 VERIFIED: YES
Provenance & Taxonomy
Viola odorata [Plant]
Cyclotide
97441
Structure & Mods
head-to-tail cyclic peptide scaffold [Cyclic]
canonical L-amino-acid peptide [L]
Cysteine-rich scaffold consistent with multiple disulfide bonds in the annotated family
Bio-Activity Profile
Antimicrobial Nematocidal Anthelmintic Molluscicidal
Haemonchus contortus
PaperThe anthelmintic activity of the cyclotides: natural variants with enhanced activity | PubMed PMID 18557620 | Plan et al. 2008 J Agric Food Chem 56: 5237 PMID18557620 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18557620/
RECORD: Rec_0397158 VERIFIED: YES
Provenance & Taxonomy
Viola odorata [Plant]
Defensin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
4-21; 8-23; 13-28
Bio-Activity Profile
Insecticidal Cytotoxic
PaperPubMed PMID: 16872274 | PubMed PMID: 10600388 | PubMed PMID: 12482868 PMID16872274;10600388;12482868 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16872274/
RECORD: Rec_0415720 VERIFIED: YES
Provenance & Taxonomy
Viola odorata [Plant]
97441
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Insecticidal
PaperPlant cyclotides: A unique family of cyclic and knotted proteins that defines the cyclic cystine knot structural motif. PMID10600388 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10600388/
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