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MYP_027968
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Basic Information
Cycloviolacin-O1 (Plant defensin)
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antiparasitic ▸ Anthelminthic
Antiparasitic ▸ Anthelminthic ▸ Nematicidal activity
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Insecticidal/Pest control ▸ Insecticidal activity
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
30 amino acids
C131H211N35O42S6
Standard
Sequence
GIPCAESCVYIPCTVTALLGCSCSNRVCYN
Physicochemical Analysis
3140.68 Da
5.96
-0.30
-0.59
-0.0100
0.75
0.36
0.24
31.05
87.67
0.0667
2980.00
3355.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1216.63
-14.98
48.0
48.0
94.0
214.0
4.0
31.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0160417 VERIFIED: YES
Provenance & Taxonomy
Viola odorata [Plant]
Cyclotide
97441
Structure & Mods
head-to-tail cyclic peptide scaffold [Cyclic]
canonical L-amino-acid peptide [L]
Cysteine-rich scaffold consistent with multiple disulfide bonds in the annotated family
Bio-Activity Profile
Antimicrobial Nematocidal Anthelmintic Molluscicidal
Trichostrongylus colubriformis
PaperThe anthelmintic activity of the cyclotides: natural variants with enhanced activity | PubMed PMID 18557620 | Plan et al. 2008 J Agric Food Chem 56: 5237 PMID18557620 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18557620/
RECORD: Rec_0167468 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial
PaperPhytAMP: a database dedicated to antimicrobial plant peptides PMID18836196 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18836196/
RECORD: Rec_0205128 VERIFIED: NO
Provenance & Taxonomy
Viola odorata [Plant]
Cyclotide
Structure & Mods
Backbone-cyclized cyclotide scaffold with cystine-knot family annotation [Cyclic]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
Evidence URLhttps://camp.bicnirrh.res.in/seqDisp.php?id=CAMPSQ6431
RECORD: Rec_0311016 VERIFIED: YES
Provenance & Taxonomy
Viola odorata [Plant]
cyclotide family
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
4-21; 8-23; 13-28
Bio-Activity Profile
Antimicrobial cyclotide family Host defense
PaperPDB 1DF6 structural record; NMR; chain A; residues 7-30
RECORD: Rec_0352293 VERIFIED: YES
Provenance & Taxonomy
Viola odorata [Plant]
Cyclotide
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Anti-Gram-negative
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
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