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MYP_027968
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Basic Information
Cycloviolacin-O1 (Plant defensin)
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antiparasitic ▸ Anthelminthic
Antiparasitic ▸ Anthelminthic ▸ Nematicidal activity
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Insecticidal/Pest control ▸ Insecticidal activity
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Standard
30 amino acids
C131H211N35O42S6
Standard
Sequence
GIPCAESCVYIPCTVTALLGCSCSNRVCYN
Physicochemical Analysis
3140.68 Da
5.96
-0.30
-0.59
-0.0100
0.75
0.36
0.24
31.05
87.67
0.0667
2980.00
3355.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1216.63
-14.98
48.0
48.0
94.0
214.0
4.0
31.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0009481 VERIFIED: YES
Provenance & Taxonomy
Viola odorata [Plant]
Defensin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
4-21; 8-23; 13-28
Bio-Activity Profile
Insecticidal Cytotoxic Anticancer
human lymphoma cell line U-937 GTB
IC50
PaperPubMed PMID: 16872274 | PubMed PMID: 10600388 | PubMed PMID: 12482868 PMID16872274;10600388;12482868 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16872274/
RECORD: Rec_0089159 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Insecticidal
PaperAPD2: the updated antimicrobial peptide database and its application in peptide design PMID18957441 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18957441/
RECORD: Rec_0122964 VERIFIED: NO
Provenance & Taxonomy
Viola odorata [Plant]; Insecta [Animal]
33090; 50557
Structure & Mods
cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
RECORD: Rec_0145189 VERIFIED: NO
Provenance & Taxonomy
Viola odorata [Plant]
Structure & Mods
cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
4-21; 8-23; 13-28
Bio-Activity Profile
Antimicrobial
RECORD: Rec_0160417 VERIFIED: YES
Provenance & Taxonomy
Viola odorata [Plant]
Cyclotide
97441
Structure & Mods
head-to-tail cyclic peptide scaffold [Cyclic]
canonical L-amino-acid peptide [L]
Cysteine-rich scaffold consistent with multiple disulfide bonds in the annotated family
Bio-Activity Profile
Antimicrobial Nematocidal Anthelmintic Molluscicidal
Trichostrongylus colubriformis
in vitro anthelmintic activity assay
PaperThe anthelmintic activity of the cyclotides: natural variants with enhanced activity | PubMed PMID 18557620 | Plan et al. 2008 J Agric Food Chem 56: 5237 PMID18618891 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18557620/
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