Peptide Database

Peptide Name28(derived from HCV C5A)

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Anti-Hepatitis virus ▸ Anti-HCV

Antiviral ▸ Antiviral mechanism ▸ Viral release inhibition

Antiviral ▸ Virucidal activity

Standard StatusStandard

Sequence Length18 amino acids

Chemical FormulaC108H155N25O28S

DescriptionStandard

        SWLRDVWDWVCTILTDFK
    

Molecular Weight2283.60 Da

Isoelectric Point (pI)4.43

Net Charge (pH 7.0)-1.55

Net Charge (pH 7.4) -1.77

Charge Density (pH 7.0) -0.0860

GRAVY Index0.11

Hydrophobic Moment 0.67

Boman Index0.14

Instability Index38.56

Aliphatic Index 97.22

Aromaticity 0.2222

Extinction Coeff. Reduced 16500.00

Extinction Coeff. Oxidized 16500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 865.90

LogP -3.00

H-bond Donors 33.0

H-bond Acceptors 28.0

Rotatable Bonds 69.0

Heavy Atoms 162.0

Ring Count 7.0

Amide Bonds 17.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0275189 VERIFIED: YES

Provenance & Taxonomy

OrganismHepatitis C virus [Virus]

FamilyVirus-derived peptide

Tax ID3052230;0

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antiviral Virucidal

TargetHepatitis C virus (Viral membrane); Huh7

Activity2.1 μM

MethodRT-PCR

PaperA virocidal amphipathic {alpha}-helical peptide that inhibits hepatitis C virus infection in vitro. | Cheng G, Montero A, Gastaminza P, Whitten-Bauer C, Wieland SF, Isogawa M, Fredericksen B, Selvarajah S, Gallay PA, Ghadiri MR, Chisari FV. | Proc Natl Acad Sci U S A. 2008 | PMID:18287023 PMID18287023 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18287023/

RECORD: Rec_0343624 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antimicrobial Antiviral

RECORD: Rec_0379043 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configsynthetic linear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antiviral

TargetHepatitis C virus HCV JFH-1

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