Peptide Database

Peptide NameProtein synthesis inhibitor II (EC 3.2.2.22) (Ribosome-inactivating protein II) (rRNA N-glycosidase)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antifungal

Enzyme / Catalytic activity ▸ Hydrolase

Enzyme modulation ▸ Enzyme inhibition ▸ Protein Synthesis Inhibitor

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Toxin

Standard StatusStandard

Sequence Length280 amino acids

Chemical FormulaC1346H2143N369O390S4

DescriptionStandard

        AAKMAKNVDKPLFTATFNVQASSADYATFIAGIRNKLRNPAHFSHNEPVLPPVEPNVPPSRWFHVVLKASPTSAGLTLAIRADNIYLEGFKSSDGTWWELTPGLIPGATYVGFGGTYRDLLGDTDKLTNVALGRQQLEDAVTALHGRTKADKASGPKQQQAREAVTTLLLMVNEATRFQTVSGFVAGLLHPKAVEKKSGKIGNEMKAQVNGWQDLSAALLKTDVKPPPGKSPAKFTPIEKMGVRTAEQAAATLGILLFVEVPGGLTVAKALELFHASGGK
    

Molecular Weight29862.91 Da

Isoelectric Point (pI)9.56

Net Charge (pH 7.0)8.34

Net Charge (pH 7.4) 7.78

Charge Density (pH 7.0) 0.0298

GRAVY Index-0.16

Hydrophobic Moment 0.64

Boman Index0.07

Instability Index32.79

Aliphatic Index 85.79

Aromaticity 0.0714

Extinction Coeff. Reduced 27960.00

Extinction Coeff. Oxidized 27960.00

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Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0311385 VERIFIED: YES

Provenance & Taxonomy

OrganismHordeum vulgare [Plant]

FamilyRibosome-inactivating protein; Type 1 RIP subfamily

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antifungal Hydrolase Protein Synthesis Inhibitor Toxin Non-hemolytic