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MYP_027857
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Basic Information
Rugosauperolein-2
Antimicrobial
Cardiovascular ▸ Vascular tone modulation ▸ Vasoactive peptide
Cardiovascular ▸ Vascular tone modulation ▸ Vasodilatory activity
Enzyme modulation ▸ Enzyme inhibition ▸ DPP-IV inhibition ▸ DPP-IV inhibitory
Metabolic ▸ Glucose metabolism ▸ Antidiabetic
Neurological / Signaling ▸ Neuromodulation
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Neurological / Signaling ▸ Tachykinin peptide
Other / Curated residual function label ▸ Generic enzyme inhibition annotation
Regulatory peptide ▸ Biological modulation
Standard
11 amino acids
C58H87N13O17S
Standard
Sequence
QADPKTFYGLM
Physicochemical Analysis
1270.45 Da
5.83
-0.24
-0.45
-0.0219
-0.42
0.25
0.10
34.51
44.55
0.1818
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
492.40
-3.36
16.0
18.0
39.0
89.0
3.0
11.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0087169 VERIFIED: YES
Provenance & Taxonomy
Uperoleia rugosa [Animal]
Tachykinin
8368
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Pyroglutamate
Amidation
Bio-Activity Profile
Tachykinin Neuropeptide Neuromodulator
PMID7389029 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/7389029/
RECORD: Rec_0137369 VERIFIED: YES
Provenance & Taxonomy
Uperoleia rugosa [Animal]
Rugosauperolein
Structure & Mods
ribosomal mature linear peptide [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
Amidation
Bio-Activity Profile
-
PaperM.A. Apponyi et al. / Peptides 25 (2004) 1035-1054. Host-defence peptides of Australian anurans: structure, mechanism of action and evolutionary significance PMID15203252 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15203252/
RECORD: Rec_0205281 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Neuropeptide
Paper数据库级溯源文献：Wang Y, Wang M, Yin S, et al. NeuroPep: a comprehensive resource of neuropeptides. Database (Oxford). 2015:bav038. PMID 25931458; Bin Y, Zhang W, Tang W, et al. Prediction of Neuropeptides from Sequence Information Using Ensemble Classifier and Hybrid Features. J Proteome Res. 2020;19(9):3732-3740. PMID 32786686. PMID25931458;32786686 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25931458/
RECORD: Rec_0234047 VERIFIED: YES
Provenance & Taxonomy
Uperoleia rugosa [Animal]
Rugosauperolein
8368
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Pyroglutamate
Amidation
Bio-Activity Profile
Neuropeptide Neuromodulator Vasoactive Vasodilator Receptor modulation
Mammalian: 0.8 hour; Yeast: 10 min; E. coli: >10 hour
PaperSource-linked PubMed record(s) for Rugosauperolein-2 (Uperoleia rugosa): PMID 7389029 PMID7389029 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/7389029/
RECORD: Rec_0296197 VERIFIED: NO
Provenance & Taxonomy
Sorghum bicolor [Plant]
45580
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Enzyme inhibitory DPP-IV inhibitory Antidiabetic
DPP-IV
PaperPurification, identification and in silico studies of antioxidant, antidiabetogenic and antibacterial peptides obtained from sorghum spent grain hydrolysate. LWT 153:112414 (2022).
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