Peptide Database

Peptide NameUnnamed

Function Ontology

Enzyme modulation ▸ Enzyme inhibition ▸ CaMKII Inhibitory

Standard StatusStandard

Sequence Length13 amino acids

Chemical FormulaC64H116N22O19S

DescriptionStandard

        KKALRRQECVDAL
    

Molecular Weight1529.81 Da

Isoelectric Point (pI)9.31

Net Charge (pH 7.0)1.75

Net Charge (pH 7.4) 1.53

Charge Density (pH 7.0) 0.1348

GRAVY Index-0.72

Hydrophobic Moment 0.42

Boman Index-0.45

Instability Index114.18

Aliphatic Index 97.69

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 706.05

LogP -6.68

H-bond Donors 26.0

H-bond Acceptors 22.0

Rotatable Bonds 55.0

Heavy Atoms 106.0

Ring Count 0.0

Amide Bonds 13.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0062866 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyAIP

Tax ID32630

Structure & Mods

Configsynthetic linear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

CaMKII Inhibitory

TargetCalmodulin-dependent protein kinase II (CaMKII)

Activity0.35 μM

MethodIC50

PaperIshida A., Shigeri Y., Tatsu Y., Uegaki K., Kameshita I., Okuno S., Kitani T., Yumoto N., Fujisawa H.. Critical amino acid residues of AIP, a highly specific inhibitory peptide of calmodulin-dependent protein kinase II. FEBS Lett.,427,115-118 (1998). PMID9613610 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/9613610/