Peptide Database

Peptide Nameephrin type-A receptor 2 (EphA2) targeting peptide

Function Ontology

Anticancer

Delivery / Targeting ▸ Drug delivery vehicle ▸ Drug delivery

Delivery / Targeting ▸ Targeting ligand ▸ Targeting

Standard StatusStandard

Sequence Length13 amino acids

Chemical FormulaC65H98N14O21S2

DescriptionStandard

        YSAYPDSVPMMSK
    

Molecular Weight1475.68 Da

Isoelectric Point (pI)5.83

Net Charge (pH 7.0)-0.24

Net Charge (pH 7.4) -0.45

Charge Density (pH 7.0) -0.0186

GRAVY Index-0.45

Hydrophobic Moment 0.31

Boman Index0.06

Instability Index68.34

Aliphatic Index 30.00

Aromaticity 0.1538

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 2980.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 559.41

LogP -5.11

H-bond Donors 19.0

H-bond Acceptors 23.0

Rotatable Bonds 43.0

Heavy Atoms 102.0

Ring Count 4.0

Amide Bonds 12.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0407720 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configsynthetic linear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermSource entry describes small-molecule/peptide conjugation at one terminus; exact terminus not explicitly assigned in source metadata

Other ModsConjugate type: amide; Conjugated small molecule: paclitaxel (PTX) derivative

Bio-Activity Profile

Function

Anticancer Drug delivery Targeting

TargetEphA2 receptor; PC3M prostate cancer cells/xenograft

MethodEphA2-targeted peptide-drug conjugate bioevaluation

RECORD: Rec_0433043 VERIFIED: YES