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MYP_027821
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Basic Information
4277(derived from DNA-polymerase domain of HIV-1 RT (20-mers))
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition
Standard
20 amino acids
C113H171N31O33
Standard
Sequence
DFRELNKRTQDFWEVQLGIP
Physicochemical Analysis
2491.75 Da
4.78
-1.23
-1.44
-0.0617
-0.95
0.65
-0.20
30.27
73.00
0.1500
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1071.74
-8.13
36.0
32.0
82.0
177.0
5.0
22.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0102582 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-HIV-1 Replication inhibition
HIV-1
Mammalian: 1.1 h; Yeast: 3 min; E. coli: >10 h
PaperPeptides derived from the reverse transcriptase of human immunodeficiency virus type 1 as novel inhibitors of the viral integrase. | Oz Gleenberg I, Avidan O, Goldgur Y, Herschhorn A, Hizi A. | J Biol Chem. 2005 Jun 10;280(23):21987-96. | DOI:10.1074/jbc.M414679200 | PMID:15790559 PMID15790559 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15790559/
RECORD: Rec_0226094 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
PaperPeptides derived from the reverse transcriptase of human immunodeficiency virus type 1 as novel inhibitors of the viral integrase PMID15790559 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15790559/
RECORD: Rec_0346914 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
HIV-1:the level of peptide binding to HIV integrase is very low
PaperPeptides derived from the reverse transcriptase of human immunodeficiency virus type 1 as novel inhibitors of the viral integrase PMID15790559 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15790559/