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MYP_027811
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Basic Information
Insulin Degludec
Hormonal / Endocrine ▸ Hormone peptide
Metabolic ▸ Glucose metabolism ▸ Antidiabetic
Metabolic ▸ Glucose metabolism ▸ Antidiabetic ▸ Hypoglycemic
Standard
50 amino acids
C253H380N64O74S6
Standard
Sequence
GIVEQCCTSICSLYQLENYCNFVNQHLCGSHLVEALYLVCGERGFFYTPK
Physicochemical Analysis
5694.50 Da
5.39
-2.12
-2.52
-0.0424
0.24
0.44
0.18
12.37
87.60
0.1400
5960.00
6335.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
2215.52
-19.76
81.0
80.0
182.0
397.0
10.0
55.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0113640 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Insulin
9606
Structure & Mods
two-chain disulfide-bonded insulin analog [Linear]
noncanonical stereochemical or chemical modification [Modified]
A6-A11, A7-B7, A20-B19
LysB29 glutamyl-C16 fatty-diacid acylation; des-B30
Bio-Activity Profile
Antidiabetic Hypoglycemic Insulin analog
approx. 25 h
PaperPubMed-linked source references: PMID:25941658; PMID:24673155; PMID:24118819; PMID:23448197; PMID:28250698; PMID:28295934; PMID:28282219; PMID:28275957; PMID:28234565 PMID25941658;24673155;24118819;23448197;28250698;28295934;28282219;28275957;28234565 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25941658/
RECORD: Rec_0394204 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]; Saccharomyces cerevisiae [Fungus]
Insulin
9606;4932
Structure & Mods
two-chain disulfide-bonded insulin analog [Linear]
noncanonical stereochemical or chemical modification [Modified]
A6-A11, A7-B7, A20-B19
LysB29 myristoylation; des-B30
Bio-Activity Profile
Antidiabetic Hypoglycemic Insulin analog
Adults (18-65 years) = 425 ± 78 min
PaperPubMed-linked source references: PMID:23512415; PMID:18454569; PMID:18034591; PMID:17881328; PMID:17901036; PMID:14578244; PMID:23551900; PMID:17443605 PMID23512415;18454569;18034591;17881328;17901036;14578244;23551900;17443605 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23512415/ PatentUS5750497