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MYP_027582
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Basic Information
T-DPH1
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
21 amino acids
C92H156N26O24
Standard
Sequence
GLWSKIKNVAAAAGKAALGAL
Physicochemical Analysis
2010.38 Da
10.30
2.76
2.55
0.1313
0.70
0.49
0.32
4.63
121.43
0.0476
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
802.49
-7.05
28.0
27.0
67.0
142.0
2.0
21.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0298857 VERIFIED: YES
Provenance & Taxonomy
Pithecopus hypochondrialis [Animal]
Dermaseptin
317381
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Anticancer
but not HaCaT
175.6 μM
IC50
PaperExploration of the Structure-Function Relationships of a Novel Frog Skin Secretion-Derived Bioactive Peptide, t-DPH1, through Use of Rational Design, Cationicity Enhancement and In Vitro Studies.
RECORD: Rec_0302207 VERIFIED: YES
Provenance & Taxonomy
Animalia [Animal]
Dermaseptin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Anticancer Cytotoxic
PMID34943741 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34943741/
RECORD: Rec_0323094 VERIFIED: YES
Provenance & Taxonomy
Pithecopus hypochondrialis [Animal]
Dermaseptin
317381
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Anticancer
Enterococcus faecalis NCTC 12697
128 μM
MIC
PaperExploration of the Structure-Function Relationships of a Novel Frog Skin Secretion-Derived Bioactive Peptide, t-DPH1, through Use of Rational Design, Cationicity Enhancement and In Vitro Studies.
RECORD: Rec_0332556 VERIFIED: YES
Provenance & Taxonomy
Pithecopus hypochondrialis [Animal]
Dermaseptin
317381
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Anticancer
Horse RBC cells: low hemo.lytic
106.4 μM
HC50
PaperExploration of the Structure-Function Relationships of a Novel Frog Skin Secretion-Derived Bioactive Peptide, t-DPH1, through Use of Rational Design, Cationicity Enhancement and In Vitro Studies.
RECORD: Rec_0388151 VERIFIED: YES
Provenance & Taxonomy
Pithecopus hypochondrialis [Animal]
Dermaseptin
317381
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Anticancer
Staphylococcus aureus ATCC 6538 or MRSA NCTC 12493
8-16 μM
MIC
PaperExploration of the Structure-Function Relationships of a Novel Frog Skin Secretion-Derived Bioactive Peptide, t-DPH1, through Use of Rational Design, Cationicity Enhancement and In Vitro Studies.
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