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MYP_027582
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Basic Information
T-DPH1
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
21 amino acids
C92H156N26O24
Standard
Sequence
GLWSKIKNVAAAAGKAALGAL
Physicochemical Analysis
2010.38 Da
10.30
2.76
2.55
0.1313
0.70
0.49
0.32
4.63
121.43
0.0476
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
802.49
-7.05
28.0
27.0
67.0
142.0
2.0
21.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0235355 VERIFIED: YES
Provenance & Taxonomy
Pithecopus hypochondrialis [Animal]
Dermaseptin
317381
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Anticancer
Pseudomonas aeruginosa ATCC 9027
16 μM
MIC
PaperExploration of the Structure-Function Relationships of a Novel Frog Skin Secretion-Derived Bioactive Peptide, t-DPH1, through Use of Rational Design, Cationicity Enhancement and In Vitro Studies.
RECORD: Rec_0238044 VERIFIED: YES
Provenance & Taxonomy
Pithecopus hypochondrialis [Animal]
Dermaseptin
317381
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Anticancer
Escherichia coli ATCC 8739
2 μM
MIC
PaperExploration of the Structure-Function Relationships of a Novel Frog Skin Secretion-Derived Bioactive Peptide, t-DPH1, through Use of Rational Design, Cationicity Enhancement and In Vitro Studies.
RECORD: Rec_0239804 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa hypochondrialis [Animal]
Dermaseptin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Pseudomonas aeruginosa ATCC 9027
16 μM
MIC
PMID34943741 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34943741/
RECORD: Rec_0274358 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa hypochondrialis [Animal]
Dermaseptin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Candida albicans ATCC 10231
64 μM
MIC
PMID34943741 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34943741/
RECORD: Rec_0280015 VERIFIED: YES
Provenance & Taxonomy
Pithecopus hypochondrialis [Animal]
Dermaseptin
317381
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Anticancer
d Escherichia coli and Staphylococcus aureus in 60 min. Antibiofilms of most of these bacteria as well. Also, this peptide has anti-proliferation of cancer cells, including PC-3, H838, H157 and U251MG
10.2-34.25 μM
IC50
PaperExploration of the Structure-Function Relationships of a Novel Frog Skin Secretion-Derived Bioactive Peptide, t-DPH1, through Use of Rational Design, Cationicity Enhancement and In Vitro Studies.
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