Peptide Database

Peptide NameNisin A

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Standard StatusStandard

Sequence Length34 amino acids

Chemical FormulaC140H243N41O46S7

DescriptionStandard

        ITSISLCTPGCKTGALMGCNMKTATCNCSVHVSK
    

Molecular Weight3461.13 Da

Isoelectric Point (pI)8.78

Net Charge (pH 7.0)2.79

Net Charge (pH 7.4) 2.46

Charge Density (pH 7.0) 0.0822

GRAVY Index0.40

Hydrophobic Moment 0.29

Boman Index0.15

Instability Index13.45

Aliphatic Index 68.82

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 250.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1389.82

LogP -20.53

H-bond Donors 54.0

H-bond Acceptors 57.0

Rotatable Bonds 114.0

Heavy Atoms 234.0

Ring Count 2.0

Amide Bonds 35.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0371705 VERIFIED: YES

Provenance & Taxonomy

OrganismLactococcus lactis [Bacterium]

FamilyBacteriocin

Tax ID1358

Structure & Mods

Configthioether-constrained cyclic peptide [Cyclic]

Chiralitynoncanonical stereochemical modification [Modified]

N-TermNone

C-TermNone

Other ModsThere are two dehydroalanines (S5; S33), one dehydrobutyrine (T2), which form one lanthionine (S3-C7) and four β-methyllanthionines (T8-C11; T13-C19; T23-C26; T25-C28)

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive

TargetLactobacillus reuteri

RECORD: Rec_0421093 VERIFIED: YES