Peptide Database

Peptide NameT-262

Function Ontology

Anticancer

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antiviral

Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition

Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition ▸ Fusion inhibitor

Therapeutic / Biomedical activity ▸ Protective bioactivity ▸ Cell protection ▸ Cytoprotection

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length35 amino acids

Chemical FormulaC160H269N43O57

DescriptionStandard

        LGPPISLERLDVGTNLGNAIAKLEDAKELLESSDQ
    

Molecular Weight3707.10 Da

Isoelectric Point (pI)4.20

Net Charge (pH 7.0)-4.23

Net Charge (pH 7.4) -4.44

Charge Density (pH 7.0) -0.1208

GRAVY Index-0.27

Hydrophobic Moment 0.54

Boman Index0.02

Instability Index17.73

Aliphatic Index 117.14

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1620.37

LogP -17.30

H-bond Donors 53.0

H-bond Acceptors 53.0

Rotatable Bonds 127.0

Heavy Atoms 260.0

Ring Count 2.0

Amide Bonds 37.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0306401 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermAcetylation

C-TermAmidation

Bio-Activity Profile

Function

Antimicrobial Antiviral

RECORD: Rec_0326400 VERIFIED: YES

Provenance & Taxonomy

OrganismMeasles morbillivirus [Virus]

FamilyVirus-derived peptide

Tax ID11234;0

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antiviral Fusion inhibitor Cytoprotective

TargetMeasles virus (Fusion); HEp2

Activity6.5 μM

MethodEC50

PaperPeptides from conserved regions of paramyxovirus fusion (F) proteins are potent inhibitors of viral fusion. | Lambert DM, Barney S, Lambert AL, Guthrie K, Medinas R, Davis DE, Bucy T, Erickson J, Merutka G, Petteway SR Jr. | Proc Natl Acad Sci U S A. 1996 | PMID:8700906 PMID8700906 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8700906/

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