Peptide Database

Peptide NameBeta-defensin

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length70 amino acids

Chemical FormulaC370H596N100O95S8

DescriptionStandard

        MRVLYSILGALALLSVVPQARTFFLKDTCSLEYLNCRMKCNLDEHAIKYCADWTICCKAKNTKFKRKKKW
    

Molecular Weight8221.82 Da

Isoelectric Point (pI)9.54

Net Charge (pH 7.0)8.52

Net Charge (pH 7.4) 8.15

Charge Density (pH 7.0) 0.1218

GRAVY Index-0.09

Hydrophobic Moment 0.54

Boman Index-0.05

Instability Index9.46

Aliphatic Index 87.86

Aromaticity 0.1143

Extinction Coeff. Reduced 15470.00

Extinction Coeff. Oxidized 15845.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 3191.65

LogP -23.41

H-bond Donors 120.0

H-bond Acceptors 113.0

Rotatable Bonds 279.0

Heavy Atoms 573.0

Ring Count 12.0

Amide Bonds 73.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0310721 VERIFIED: NO

Provenance & Taxonomy

OrganismCanis lupus familiaris [Animal]

FamilyDefensin

Tax ID9615

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Defensin Non-hemolytic Non-ribosomal

MethodQualitative functional evidence

PaperCross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract PMID16033865 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16033865/; https://www.uniprot.org/uniprotkb/Q30KS3/entry; https://bblserver.org.in/ampdb/