‹ ›
MYP_027446
← PREVIOUS NEXT → BACK
Basic Information
Hn-Mc (a chimeric peptide comprised of the N-terminus of HPA3NT3 and the C-terminus of melittin)
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Immunology ▸ Inflammation modulation ▸ Anti-inflammatory
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
17 amino acids
C105H182N34O21
Standard
Sequence
FKRLKKLISWIKRKRQQ
Physicochemical Analysis
2256.78 Da
12.00
7.76
7.54
0.4562
-1.31
0.74
-0.59
65.78
91.76
0.1176
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
966.92
-5.74
36.0
29.0
84.0
160.0
3.0
18.0
Structural Visualization
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.
2D CHEMICAL STRUCTURE
Drag to move
Drag to move. Use the buttons to zoom.
Experimental Records
RECORD: Rec_0348405 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Melittin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Anti-inflammatory
Drug-susceptible gram-positive bacteria:Staphylococcus aureus
2 μM
MIC
PMID32731574;26028561 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32731574/
RECORD: Rec_0351530 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Melittin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Anti-inflammatory
krusei
8 μM
MIC
PMID32731574;26028561 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32731574/
RECORD: Rec_0362298 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Melittin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Pseudomonas aeruginosa
01-2 μM
MIC
PMID26028561;32731574 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26028561/
RECORD: Rec_0374680 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Melittin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Anti-inflammatory
Staphylococcus aureus DRSA-004
2 μM
MIC
PMID32731574;26028561 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32731574/
RECORD: Rec_0385805 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Melittin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Anti-inflammatory
flavus
2-4 μM
MIC
PMID32731574;26028561 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32731574/
FIRST PREV 1 ... 7 8 9 10 NEXT LAST
Showing 5 records on this page · Page 9 of 10