Peptide Database

Peptide NameHn-Mc (a chimeric peptide comprised of the N-terminus of HPA3NT3 and the C-terminus of melittin)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antifungal

Immunology ▸ Inflammation modulation ▸ Anti-inflammatory

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Standard StatusStandard

Sequence Length17 amino acids

Chemical FormulaC105H182N34O21

DescriptionStandard

        FKRLKKLISWIKRKRQQ
    

Molecular Weight2256.78 Da

Isoelectric Point (pI)12.00

Net Charge (pH 7.0)7.76

Net Charge (pH 7.4) 7.54

Charge Density (pH 7.0) 0.4562

GRAVY Index-1.31

Hydrophobic Moment 0.74

Boman Index-0.59

Instability Index65.78

Aliphatic Index 91.76

Aromaticity 0.1176

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 966.92

LogP -5.74

H-bond Donors 36.0

H-bond Acceptors 29.0

Rotatable Bonds 84.0

Heavy Atoms 160.0

Ring Count 3.0

Amide Bonds 18.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0362298 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyMelittin

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Other ModsC-terminal amidation

Bio-Activity Profile

Function

Antimicrobial Antibacterial Antifungal

TargetPseudomonas aeruginosa

Activity1-2 μM

MethodMIC

RECORD: Rec_0374680 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyMelittin

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermAmidation

Other ModsC-terminal amidation

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Anti-inflammatory

TargetStaphylococcus aureus DRSA-004

Activity2 μM

MethodMIC

RECORD: Rec_0385805 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyMelittin

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermAmidation

Other ModsC-terminal amidation

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Anti-inflammatory

TargetAspergillus flavus

Activity2-4 μM

MethodMIC

RECORD: Rec_0391944 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyMelittin

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermAmidation

Other ModsC-terminal amidation

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Anti-inflammatory

TargetTrichosporon beigelii

Activity1 μM

MethodMIC

RECORD: Rec_0418686 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyMelittin

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermAmidation

Other ModsC-terminal amidation

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Anti-inflammatory

TargetEscherichia coli

Activity1 μM

MethodMIC

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