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MYP_027446
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Basic Information
Hn-Mc (a chimeric peptide comprised of the N-terminus of HPA3NT3 and the C-terminus of melittin)
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Immunology ▸ Inflammation modulation ▸ Anti-inflammatory
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
17 amino acids
C105H182N34O21
Standard
Sequence
FKRLKKLISWIKRKRQQ
Physicochemical Analysis
2256.78 Da
12.00
7.76
7.54
0.4562
-1.31
0.74
-0.59
65.78
91.76
0.1176
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
966.92
-5.74
36.0
29.0
84.0
160.0
3.0
18.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0172692 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Melittin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Staphylococcus aureus
01-2 μM
MIC
PMID26028561;32731574 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26028561/
RECORD: Rec_0176140 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Melittin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Anti-inflammatory
parapsilosis
16 μM
MIC
PMID32731574;26028561 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32731574/
RECORD: Rec_0192260 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Melittin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Candida parapsilosis CCARM 14016
16 μM
MIC
PMID26028561;32731574 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26028561/
RECORD: Rec_0228119 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Melittin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Anti-inflammatory
Staphylococcus aureus DRSA-005
2 μM
MIC
PMID32731574;26028561 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32731574/
RECORD: Rec_0250862 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Melittin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Anti-inflammatory
Pseudomonas aeruginosa
2 μM
MIC
PMID32731574;26028561 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32731574/
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