Peptide Database

Peptide NameSLAY-screened peptide P3661

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length12 amino acids

Chemical FormulaC47H83N15O17S3

DescriptionStandard

        CRMTITSGASCP
    

Molecular Weight1226.45 Da

Isoelectric Point (pI)8.07

Net Charge (pH 7.0)0.74

Net Charge (pH 7.4) 0.51

Charge Density (pH 7.0) 0.0617

GRAVY Index0.31

Hydrophobic Moment 0.23

Boman Index0.07

Instability Index42.91

Aliphatic Index 40.83

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 125.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 517.45

LogP -8.44

H-bond Donors 21.0

H-bond Acceptors 21.0

Rotatable Bonds 37.0

Heavy Atoms 82.0

Ring Count 1.0

Amide Bonds 11.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0069424 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/