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MYP_027414
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Basic Information
Beta-defensin 114 (Beta-defensin 14, DEFB-14; Defensin, beta 114; Human, mammals, animals)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Standard
43 amino acids
C217H356N64O71S7
Standard
Sequence
DRCTKRYGRCKRDCLESEKQIDICSLPRKICCTEKLYEEDDMF
Physicochemical Analysis
5221.99 Da
6.37
-0.29
-0.60
-0.0067
-1.01
0.70
-0.41
67.11
54.42
0.0698
2980.00
3355.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
2253.80
-22.68
86.0
78.0
183.0
359.0
4.0
43.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0000298 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Defensin
9606
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Disulfide bond(s) reported
Bio-Activity Profile
Antimicrobial Antibacterial
PaperPubMed PMID: 16033865 | PubMed PMID: 11854508 PMID16033865;11854508 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16033865/
RECORD: Rec_0044597 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Defensin
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal
Escherichia coli, Staphylococcus aureus
PaperThe novel human beta-defensin 114 regulates lipopolysaccharide(LPS)-mediated inflammation and protects sperm from motility loss
RECORD: Rec_0048719 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 9.3%, E 32.6%, T 20.9%, C 37.2% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antibacterial Antimicrobial Antifungal Anti-Gram-positive Anti-Gram-negative
PaperAPD2: the updated antimicrobial peptide database and its application in peptide design PMID18957441 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18957441/
RECORD: Rec_0070222 VERIFIED: NO
Provenance & Taxonomy
Homo sapiens [Animal]
Defensin
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Staphylococcus aureus bacteria; Escherichia coli, Candida albicans
RECORD: Rec_0195286 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PMID23483218 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23483218/
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