Peptide Database

Peptide NameSLAY-screened peptide P4005

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC107H168N30O29

DescriptionStandard

        TSTTWVLDITPHPKYPRRGL
    

Molecular Weight2338.66 Da

Isoelectric Point (pI)9.98

Net Charge (pH 7.0)1.48

Net Charge (pH 7.4) 1.24

Charge Density (pH 7.0) 0.0742

GRAVY Index-0.71

Hydrophobic Moment 0.54

Boman Index-0.09

Instability Index23.09

Aliphatic Index 73.00

Aromaticity 0.1000

Extinction Coeff. Reduced 6990.00

Extinction Coeff. Oxidized 6990.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 942.82

LogP -8.16

H-bond Donors 34.0

H-bond Acceptors 32.0

Rotatable Bonds 68.0

Heavy Atoms 166.0

Ring Count 7.0

Amide Bonds 19.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0175735 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/