Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length473 amino acids

Chemical FormulaC2371H3778N606O664S17

DescriptionStandard

        DKGEKMLKTWYSFLLCWLSMRLEANPGLKVRITQKGLDYGRGIGMELLKQAVLKETFPSWSGQESFSVVKVNYVISRLRINAIDFPETSASFIPGTGIRLSVAHASATISADWRMNAWLLKDQGGITVSISGLFIAVIIKVSKDSTGRLSMLLHNCQLSISSVKVKLNGGSSWIYSFISGYLEKPIHTKLDKNLCLNIRYKIQMMDAQLRKHMVLSQIDAFAQIDYSLVSSPAVFKSHINLDLKGTVYPVGNHTDPPFVPAPFALPNQGDSMLYLGVSSYFLKSALLAYYRAGAFNITISEELATTFNLNIALFKDFVPEIAPSYVTACPVLLKLVATSPPAVSLSADSCILQITGCVEALAVLPNSTTQYIFTGNLTASTRANLTITKQKLIISLLLKRLQFSLLHSTLGFSKMSLVENFLSYALRSAVIPVINDELGKGFPLLTLAHATLTGSVIKMNQGHLVISTDVHYK
    

Molecular Weight51942.13 Da

Isoelectric Point (pI)9.37

Net Charge (pH 7.0)14.58

Net Charge (pH 7.4) 13.68

Charge Density (pH 7.0) 0.0308

GRAVY Index0.27

Hydrophobic Moment 0.71

Boman Index0.18

Instability Index32.72

Aliphatic Index 109.47

Aromaticity 0.0909

Extinction Coeff. Reduced 56840.00

Extinction Coeff. Oxidized 57215.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0232458 VERIFIED: NO

Provenance & Taxonomy

OrganismChlamydotis macqueenii [Animal]

FamilyBPI/LBP

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic

TargetGram-negative bacteria