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MYP_027309
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Basic Information
Cecropin-B
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antiparasitic ▸ Antimalarial
Antiparasitic ▸ Antiprotozoal ▸ Antimalarial ▸ Anti-Plasmodium
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Antiviral
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition ▸ Replication inhibitor
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
35 amino acids
C176H301N51O42S
Standard
Sequence
KWKVFKKIEKMGRNIRNGIVKAGPAIAVLGEAKAL
Physicochemical Analysis
3835.65 Da
10.73
6.76
6.54
0.1931
-0.07
0.89
0.00
35.42
106.00
0.0571
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1526.44
-10.11
53.0
50.0
136.0
270.0
4.0
36.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0096972 VERIFIED: YES
Provenance & Taxonomy
Hyalophora cecropia [Animal]
Cecropin
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Xenorhabdus nematophilus Xn21 (MLC=1.6 μM)
PaperPubMed PMID: 7140755 PMID7140755 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/7140755/
RECORD: Rec_0108893 VERIFIED: YES
Provenance & Taxonomy
Hyalophora cecropia [Animal]
Cecropin/Melittin hybrid
7123
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antiparasitic Antimalarial
Plasmodium falciparum 3D7
500 μg/mL
Microscopy (2% mercurochrome staining of midguts)
PaperEffects of magainins and cecropins on the sporogonic development of malaria parasites in mosquitoes PMID2759705 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/2759705/
RECORD: Rec_0110272 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]; Cecropia moth [Animal]; Insecta [Animal]
Cecropin
32630; 33208; 50557
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anticancer
PMID7849420 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/7849420/
RECORD: Rec_0111626 VERIFIED: YES
Provenance & Taxonomy
Insecta [Animal]
Cecropin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Replication inhibitor
Junin virus (Protein synthesis); Vero
3.4 μM
EC50
PaperAntiviral activity of antimicrobial cationic peptides against Junin virus and herpes simplex virus. | Albiol Matanic VC, Castilla V. | Int J Antimicrob Agents. 2004 | PMID:15081088 PMID15081088 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15081088/
RECORD: Rec_0115903 VERIFIED: YES
Provenance & Taxonomy
Hyalophora cecropia [Animal]
Cecropin/Melittin hybrid
7123
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antiparasitic Antimalarial
Plasmodium falciparum NF54
500 μg/mL
Microscopy (2% mercurochrome staining of midguts)
PaperEffects of magainins and cecropins on the sporogonic development of malaria parasites in mosquitoes PMID2759705 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/2759705/
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