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MYP_027309
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Basic Information
Cecropin-B
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antiparasitic ▸ Antimalarial
Antiparasitic ▸ Antiprotozoal ▸ Antimalarial ▸ Anti-Plasmodium
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Antiviral
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition ▸ Replication inhibitor
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
35 amino acids
C176H301N51O42S
Standard
Sequence
KWKVFKKIEKMGRNIRNGIVKAGPAIAVLGEAKAL
Physicochemical Analysis
3835.65 Da
10.73
6.76
6.54
0.1931
-0.07
0.89
0.00
35.42
106.00
0.0571
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1526.44
-10.11
53.0
50.0
136.0
270.0
4.0
36.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0066920 VERIFIED: YES
Provenance & Taxonomy
Hyalophora cecropia [Animal]
Cecropin
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Micrococcus luteus M111 (MLC=1.3 μM)
PaperPubMed PMID: 7140755 PMID7140755 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/7140755/
RECORD: Rec_0074037 VERIFIED: YES
Provenance & Taxonomy
Hyalophora cecropia [Animal]
Cecropin
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Bacillus megaterium Bmll (MLC=0.44 μM)
PaperPubMed PMID: 7140755 PMID7140755 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/7140755/
RECORD: Rec_0089571 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial
Papervan Hofsten P., Faye I., Kockum K., Lee J.-Y., Xanthopolous K. G., Boman I. A., Boman H. G., Engstrem A., Andreu D., Merrifield R. B.. Molecular cloning, cDNA sequencing, and chemical synthesis of secropin B from Hyalophora cecropia. Proc. Natl Acad. Sci. USA, 82, 2240-2243, 1985.
RECORD: Rec_0091301 VERIFIED: YES
Provenance & Taxonomy
Hyalophora cecropia [Animal]
Cecropin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Serratia marcescens Strain 122
PMID7140755;28556271;30823998 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/7140755/
RECORD: Rec_0093316 VERIFIED: YES
Provenance & Taxonomy
Hyalophora cecropia [Animal]
Cecropin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antibacterial
MAC15A
37 μM
IC50
PMID7849420 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/7849420/
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