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MYP_027261
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Basic Information
Defensin AMP1
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Anti-biofilm ▸ Biofilm inhibition
Antimicrobial ▸ Antifungal
Antimicrobial ▸ Antifungal ▸ Fungicidal activity
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Plant bioactivity ▸ Plant defense peptide
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
54 amino acids
C251H378N76O77S8
Standard
Sequence
DGVKLCDVPSGTWSGHCGSSSKCSQQCKDREHFAYGGACHYQFPSVKCFCKRQC
Physicochemical Analysis
5948.67 Da
8.49
2.94
2.46
0.0545
-0.61
0.38
-0.11
57.07
27.04
0.1111
8480.00
8980.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
2467.63
-32.52
94.0
91.0
193.0
412.0
12.0
57.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0121907 VERIFIED: YES
Provenance & Taxonomy
Heuchera sanguinea [Animal]
Defensin
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Disulfide bond(s) reported
Bio-Activity Profile
Antimicrobial Antifungal
Penicillium digitatum
1 μg/mL
IC50
PaperIsolation and characterisation of plant defensins from seeds of Asteraceae, Fabaceae, Hippocastanaceae and Saxifragaceae. FEBS Lett. 1995 Jul 17;368(2):257-262. doi: 10.1016/0014-5793(95)00666-W. PMID: 7628617. | PubMed PMID: 9405418 | PubMed PMID: 16284838 PMID7628617;9405418;16284838 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/7628617/
RECORD: Rec_0128724 VERIFIED: YES
Provenance & Taxonomy
Heuchera sanguinea [Plant]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Cysteine-rich scaffold consistent with multiple disulfide bonds in the annotated family
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Antibiofilm
Septoria tritici
3 μg/mL
IC50
PMID7628617;24092498 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/7628617/
RECORD: Rec_0130786 VERIFIED: YES
Provenance & Taxonomy
Insecta [Animal]
50557
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PMID2298215 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/2298215/
RECORD: Rec_0133391 VERIFIED: YES
Provenance & Taxonomy
Heuchera sanguinea [Plant]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Cysteine-rich scaffold consistent with multiple disulfide bonds in the annotated family
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Antibiofilm
Penicillium digitatum
3 μg/mL
IC50
PMID7628617;24092498 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/7628617/
RECORD: Rec_0137679 VERIFIED: YES
Provenance & Taxonomy
Heuchera sanguinea [Plant]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Cysteine-rich scaffold consistent with multiple disulfide bonds in the annotated family
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Antibiofilm Anti-Gram-negative
Escherichia coli
PMID7628617;24092498 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/7628617/
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