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MYP_027261
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Basic Information
Defensin AMP1
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Anti-biofilm ▸ Biofilm inhibition
Antimicrobial ▸ Antifungal
Antimicrobial ▸ Antifungal ▸ Fungicidal activity
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Plant bioactivity ▸ Plant defense peptide
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
54 amino acids
C251H378N76O77S8
Standard
Sequence
DGVKLCDVPSGTWSGHCGSSSKCSQQCKDREHFAYGGACHYQFPSVKCFCKRQC
Physicochemical Analysis
5948.67 Da
8.49
2.94
2.46
0.0545
-0.61
0.38
-0.11
57.07
27.04
0.1111
8480.00
8980.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
2467.63
-32.52
94.0
91.0
193.0
412.0
12.0
57.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0306388 VERIFIED: YES
Provenance & Taxonomy
Heuchera sanguinea [Plant]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Cysteine-rich scaffold consistent with multiple disulfide bonds in the annotated family
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Antibiofilm
Trichoderma viride
15 μg/mL
IC50
PMID7628617;24092498 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/7628617/
RECORD: Rec_0306492 VERIFIED: YES
Provenance & Taxonomy
Heuchera sanguinea [Plant]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Cysteine-rich scaffold consistent with multiple disulfide bonds in the annotated family
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Antibiofilm
Verticillium albo-atrum
12 μg/mL
IC50
PMID7628617;24092498 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/7628617/
RECORD: Rec_0315200 VERIFIED: YES
Provenance & Taxonomy
Heuchera sanguinea [Plant]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Cysteine-rich scaffold consistent with multiple disulfide bonds in the annotated family
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Antibiofilm
Septoria tritici
0.5 μg/mL
IC50
PMID7628617;24092498 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/7628617/
RECORD: Rec_0335474 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
PaperOsborn R. W., De Samblanx G. W., Thevissen K., Goderis I., Torrekens S., Van Leuven F., Attenborough S., Rees S. B., Broekaert W.. Isolation and characterisation of plant defensins from seeds of Asteraceae, Fabaceae, Hippocastenaceae and Saxifragaceae. FEBS LETT., 368, 257-262.
RECORD: Rec_0339594 VERIFIED: YES
Provenance & Taxonomy
Heuchera sanguinea [Plant]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Cysteine-rich scaffold consistent with multiple disulfide bonds in the annotated family
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Antibiofilm
Fusarium culmorum
0.9 μg/mL
IC50
PMID7628617;24092498 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/7628617/
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