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MYP_027094
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Basic Information
Unnamed
Antimicrobial
Cardiovascular ▸ Blood pressure regulation ▸ Antihypertensive
Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Other / Curated residual function label ▸ Generic enzyme inhibition annotation
Sensory / Food function ▸ Taste-active peptide ▸ Bitter peptide
Standard
9 amino acids
C51H85N19O11
Standard
Sequence
RPKHPIKHQ
Physicochemical Analysis
1140.34 Da
11.17
2.93
2.63
0.3258
-2.32
0.36
-0.62
17.66
43.33
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
492.93
-3.95
16.0
16.0
36.0
81.0
4.0
9.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0078766 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
alpha-S1-Casein-derived
9913
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
ACE inhibitory Antihypertensive
Angiotensin-converting enzyme (ACE)
13.4 μM
IC50
PaperIsolation and Structural Analysis of Antihypertensive Peptides That Exist Naturally in Gouda Cheese | Saito, T. et al. | DOI: 10.3168/jds.S0022-0302(00)75013-2 Evidence URLhttps://www.uniprot.org/uniprotkb/P02662/entry
RECORD: Rec_0122298 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
9913
Structure & Mods
proteolytic peptide fragment [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antihypertensive ACE inhibitory
Angiotensin-converting enzyme (rabbit lung ACE)
ACE inhibition assay
PaperIsolation and structural analysis of antihypertensive peptides that exist naturally in Gouda cheese PMID10908049 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10908049/
RECORD: Rec_0130762 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Casein-derived peptide
9913
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Enzyme inhibitory Neuropeptide ACE inhibitory
Angiotensin-I converting enzyme
13 μM
IC50
RECORD: Rec_0135422 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
9913
Structure & Mods
proteolytic peptide fragment [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antihypertensive ACE inhibitory
Angiotensin-converting enzyme (ACE)
180 μg/mL
IC50
PaperAngiotensin converting enzyme-inhibitory activity in Cheddar cheeses made with the addition of probiotic Lactobacillus casei sp.
RECORD: Rec_0155192 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
9913
Structure & Mods
proteolytic peptide fragment [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antihypertensive ACE inhibitory
Angiotensin-converting enzyme (ACE)
PaperVariability of hydrolysis of β-, αs1-, and αs2-caseins by 10 strains of Streptococcus thermophilus and resulting bioactive peptides; Isolation and structural analysis of antihypertensive peptides that exist naturally in Gouda cheese PMID22103626;10908049 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22103626/
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