Peptide Database

Peptide NameEngrailed (454-513)

Function Ontology

Delivery / Targeting ▸ Cell penetration ▸ Cell-penetrating peptide

Delivery / Targeting ▸ Drug delivery vehicle

Standard StatusStandard

Sequence Length61 amino acids

Chemical FormulaC323H535N105O95

DescriptionStandard

        EKRPRTAFSSEQLARLKREFNENRYLTTERRRQQLSSELGLNEAQIKIWFQNKRAKIKKST
    

Molecular Weight7409.35 Da

Isoelectric Point (pI)10.97

Net Charge (pH 7.0)8.85

Net Charge (pH 7.4) 8.65

Charge Density (pH 7.0) 0.1450

GRAVY Index-1.36

Hydrophobic Moment 0.65

Boman Index-0.47

Instability Index67.52

Aliphatic Index 64.10

Aromaticity 0.0820

Extinction Coeff. Reduced 6990.00

Extinction Coeff. Oxidized 6990.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 3406.77

LogP -37.84

H-bond Donors 122.0

H-bond Acceptors 104.0

Rotatable Bonds 265.0

Heavy Atoms 523.0

Ring Count 7.0

Amide Bonds 69.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0157005 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

FamilyEngrailed

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermGFP conjugation

Bio-Activity Profile

Function

Cell-penetrating peptide Cargo delivery

RECORD: Rec_0350968 VERIFIED: YES

Provenance & Taxonomy

OrganismDrosophila melanogaster [Animal]

FamilyProtein-derived CPP

Tax ID7227

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermProtein fusion

Other ModsC-term detail: Bound with GFP

Bio-Activity Profile

Function

Cell-penetrating peptide

TargetDrosophila S2 cells

MethodCellular uptake assay