‹ ›
MYP_026964
← PREVIOUS NEXT → BACK
Basic Information
MERS-S (1260-1280) [Y5,S9Ala-4-pen]
Antimicrobial
Antiviral
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor
not Standard
21 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
LDLTXEMLXLQQVVKALNESY
Physicochemical Analysis
0.00 Da
0.00
0.00
0.00
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.
2D CHEMICAL STRUCTURE
Drag to move
Drag to move. Use the buttons to zoom.
Experimental Records
RECORD: Rec_0350008 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
side-chain cyclized peptide [Cyclic]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
①The 'X' (position: 5 and 9) in sequence indicates S5 stapling amino acid. Note: S5 is (S)-pentenyl alanine. ②X (5) and X (9) are cross-linked by hydrocarbon stapling
Bio-Activity Profile
Antimicrobial Antiviral
PMID29442512 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29442512/
RECORD: Rec_0385987 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Fusion-inhibitory peptide
32630
Structure & Mods
cyclic peptide architecture [Cyclic]
noncanonical stereochemical modification [Modified]
Acetylation
Amidation
①The 'X' (position: 5 and 9) in sequence indicates S5 stapling amino acid. Note: S5 is (S)-pentenyl alanine. ②X (5) and X (9) are cross-linked by hydrocarbon stapling.
Bio-Activity Profile
Antiviral Anti-MERS-CoV Fusion inhibition
MERS-CoV | Huh-7 cells
7.14±0.7 μM
EC50
Mammalian: 5.5 h; Yeast: 3 min; E. coli: 2 min
PaperDiscovery of Hydrocarbon-Stapled Short α-Helical Peptides as Promising Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Fusion Inhibitors. | Wang C, Xia S, Zhang P, Zhang T, Wang W, Tian Y, Meng G, Jiang S, Liu K. | J Med Chem. 2018 Mar 8;61(5):2018-2026. | DOI:10.1021/acs.jmedchem.7b01732 | PMID:29442512 PMID29442512 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29442512/
FIRST PREV 1 2
Showing 2 records on this page · Page 2 of 2