‹ ›
MYP_026964
← PREVIOUS NEXT → BACK
Basic Information
MERS-S (1260-1280) [Y5,S9Ala-4-pen]
Antimicrobial
Antiviral
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor
not Standard
21 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
LDLTXEMLXLQQVVKALNESY
Physicochemical Analysis
0.00 Da
0.00
0.00
0.00
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.
2D CHEMICAL STRUCTURE
Drag to move
Drag to move. Use the buttons to zoom.
Experimental Records
RECORD: Rec_0045696 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
unspecified non-canonical residue at 5,9
Bio-Activity Profile
Antiviral
MERS-CoV
PMID29442512 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29442512/
RECORD: Rec_0142919 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
side-chain cyclized peptide [Cyclic]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
①The 'X' (position: 5 and 9) in sequence indicates S5 stapling amino acid. Note: S5 is (S)-pentenyl alanine. ②X (5) and X (9) are cross-linked by hydrocarbon stapling
Bio-Activity Profile
Antimicrobial Antiviral
MERS-CoV:inhibition of cell-cell fusion in Huh-7 cells
7.14±0.7 μM
EC50
PMID29442512 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29442512/
RECORD: Rec_0177617 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
The 'X' at position 5 and 9 are S5((S)-pentenyl alanine)
Bio-Activity Profile
Antimicrobial Antiviral
PMID29442512 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29442512/
RECORD: Rec_0198724 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
The 'X' at position 5 and 9 are S5((S)-pentenyl alanine)
Bio-Activity Profile
Antimicrobial Antiviral
MERS-CoV:inhibition of cell-cell fusion in Huh-7 cells
8.21±0.9 μM
EC50
PMID29442512 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29442512/
RECORD: Rec_0319920 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Fusion-inhibitory peptide
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Acetylation
Amidation
The 'X' at position 5 and 9 are S5((S)-pentenyl alanine)
Bio-Activity Profile
Antiviral Anti-MERS-CoV Fusion inhibition
MERS-CoV | Huh-7 cells
8.21±0.9 μM
EC50
Mammalian: 5.5 h; Yeast: 3 min; E. coli: 2 min
PaperDiscovery of Hydrocarbon-Stapled Short α-Helical Peptides as Promising Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Fusion Inhibitors. | Wang C, Xia S, Zhang P, Zhang T, Wang W, Tian Y, Meng G, Jiang S, Liu K. | J Med Chem. 2018 Mar 8;61(5):2018-2026. | DOI:10.1021/acs.jmedchem.7b01732 | PMID:29442512 PMID29442512 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29442512/
1 2 NEXT LAST
Showing 5 records on this page · Page 1 of 2