Peptide Database

Peptide NameLantibiotic

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antibiotic activity

Standard StatusStandard

Sequence Length57 amino acids

Chemical FormulaC279H453N73O87S5

DescriptionStandard

        MRYFQMAKQQMNLIEIEAMNSLQELDNVLGAGGGAIQTIVLSNQFYSDKTMVIVITN
    

Molecular Weight6382.34 Da

Isoelectric Point (pI)4.51

Net Charge (pH 7.0)-2.49

Net Charge (pH 7.4) -2.72

Charge Density (pH 7.0) -0.0437

GRAVY Index0.14

Hydrophobic Moment 0.53

Boman Index0.16

Instability Index42.08

Aliphatic Index 102.63

Aromaticity 0.0702

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 2980.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2629.19

LogP -25.41

H-bond Donors 87.0

H-bond Acceptors 90.0

Rotatable Bonds 221.0

Heavy Atoms 444.0

Ring Count 4.0

Amide Bonds 67.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0297131 VERIFIED: NO

Provenance & Taxonomy

OrganismStreptococcus parasanguinis [Bacterium]

FamilyLantibiotic

Structure & Mods

Configthioether-cyclized lantibiotic scaffold [Cyclic]

Chiralitypost-translationally modified ribosomal peptide [Modified]

Other ModsLanthionine/methyllanthionine-type thioether crosslinks are implied by the lantibiotic annotation

Bio-Activity Profile

Function

Antibiotic Antimicrobial Bacteriocin Lantibiotic Anti-Gram-positive

TargetGram-positive bacteria