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MYP_026922
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Basic Information
AOD
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
37 amino acids
C181H262N52O51S6
Standard
Sequence
GYGCPFNQYQCHSHCSGIRGYKGGYCKGTFKQTCKCY
Physicochemical Analysis
4174.72 Da
9.04
4.87
4.46
0.1315
-0.79
0.41
-0.08
11.18
10.54
0.1892
7450.00
7825.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1679.90
-20.24
65.0
64.0
133.0
290.0
10.0
40.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0138336 VERIFIED: YES
Provenance & Taxonomy
Ornithodoros tholozani [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0206569 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antibacterial Toxic Antimicrobial Hemolytic
PaperHemolytik: a database of experimentally determined hemolytic and non-hemolytic peptides PMID24174543 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24174543/
RECORD: Rec_0248534 VERIFIED: NO
Provenance & Taxonomy
Ornithodoros moubata [Animal]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
PaperInsect Biochem Mol Biol. 2001 Jun 22;31(8):747-51. | http://www.ncbi.nlm.nih.gov/pubmed/11378409 PMID11378409 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11378409/
RECORD: Rec_0296773 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
4-26; 11-34; 15-36
Bio-Activity Profile
Antimicrobial
PMID8939880 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8939880/
RECORD: Rec_0334844 VERIFIED: YES
Provenance & Taxonomy
Ornithodoros moubata [Animal]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
Staphylococcus aureus. Updated 7/2021
PaperTwo isoforms of a member of the arthropod defensin family from the soft tick, Ornithodoros moubata (Acari: Argasidae).
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