Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length443 amino acids

Chemical FormulaC2174H3405N543O651S27

DescriptionStandard

        MLQSGIVVLILLSCTYGENPAVQVVLTDKGLQYGKHAATDWIQERLEMITFPDISGDVDILIGTVDYTLTGITIKKCDIPEPSVEFLQDVPGFKASISGLCVALTGEWRTQFGIIHDGGTFDMAILNIDLTSVVQLGKEDDGHLTVTSVSCDAQVGDVDIHFYGGGSFFFNPFVSHFKGKIIDEIQKRLCPGVEENINSVESHLHAMNVSFDVNEVLTLDLPLTAVPMIGASSMNLGLKGEFYNIKTHKEPPYEAQPFTMPDAPSYMLSVGMSDFTLNTASYGYYSDNLLQLLVNDSMIPSISPVRLNTTSMGKYIPQLAKMYPDMLMNVLVYARDAPMVSTQPDAVKVIIKAAAKASAIHPNGTQIPLFTLNAVSSLDSENSLMSAFCPSFPDMCFSVAEKLGAGFVVLRMKYAELVNSVLSMEEVSICKRTHIRTNVWLFG
    

Molecular Weight48430.29 Da

Isoelectric Point (pI)4.79

Net Charge (pH 7.0)-19.65

Net Charge (pH 7.4) -20.60

Charge Density (pH 7.0) -0.0444

GRAVY Index0.18

Hydrophobic Moment 0.70

Boman Index0.18

Instability Index39.22

Aliphatic Index 96.77

Aromaticity 0.0858

Extinction Coeff. Reduced 37360.00

Extinction Coeff. Oxidized 37860.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0253113 VERIFIED: NO

Provenance & Taxonomy

OrganismAmphilophus citrinellus [Bacterium]

FamilyBPI

Tax ID61819

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence