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MYP_026899
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Basic Information
Dermaseptin-S4
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Antimalarial
Antiparasitic ▸ Antiprotozoal
Antiparasitic ▸ Antiprotozoal ▸ Antimalarial ▸ Anti-Plasmodium
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Antiviral
Antiviral ▸ Anti-Herpesvirus ▸ Anti-HSV
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Delivery / Targeting ▸ Cell penetration ▸ Cell-penetrating peptide
Delivery / Targeting ▸ Drug delivery vehicle
Enzyme modulation ▸ Enzyme inhibition ▸ CPE inhibition
Enzyme modulation ▸ Enzyme inhibition ▸ Infection inhibition
Reproductive biology ▸ Contraceptive activity ▸ Spermicidal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
28 amino acids
C132H229N35O32S
Standard
Sequence
ALWMTLLKKVLKAAAKAALNAVLVGANA
Physicochemical Analysis
2850.51 Da
10.48
3.79
3.60
0.1354
1.03
0.71
0.34
10.37
146.79
0.0357
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1075.30
-6.33
37.0
37.0
96.0
200.0
2.0
29.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0105908 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa sauvagii [Animal]
Dermaseptin
8395
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antiviral Anti-HIV-1 Infection inhibition
Human immunodeficiency virus type 1 (HIV-1) | P4-CCR5 cells
2 μM
IC50
Mammalian: 4.4 h; Yeast: >20 h; E. coli: >10 h
PaperThe antimicrobial peptide dermaseptin S4 inhibits HIV-1 infectivity in vitro. | Lorin C, Saidi H, Belaid A, Zairi A, Baleux F, Hocini H, Bélec L, Hani K, Tangy F. | Virology. 2005 Apr 10;334(2):264-75. | DOI:10.1016/j.virol.2005.02.002 | PMID:15780876 PMID15780876 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15780876/
RECORD: Rec_0108730 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa sauvagei [Animal]
Dermaseptin
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Hemolytic
PMID8306981 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8306981/
RECORD: Rec_0109351 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa sauvagei [Animal]
Dermaseptin
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
[Swiss_Prot Entry P80280]Possesses a potent antimicrobial activity against Gram-negative and Gram-positive bacteria
PMID8306981 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8306981/
RECORD: Rec_0118831 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Dermaseptin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
E. coli Urine DS, S2 = E. coli Urine MDR, S3 = K. pneumoniae Urine DS, S4 = C. striatum Wound exudate MDR, S5 = C. striatum Wound exudate MDR, S6 = C. striatum Wound exudate MDR, S7 = C. striatum Wound exudate MDR (DS = drug sensitive, MDR = multi drug resistant), C-terminal: CONH2
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
S7
275.73 μg/mL
MIC
PMID33774792 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/33774792/
RECORD: Rec_0119379 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa sauvagii [Animal]
Dermaseptin
8395
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Antiviral Antiparasitic Spermicidal
Staphylococcus aureus
13-29 μg/mL
MIC
PaperThe Vertebrate Peptide Antibiotics Dermaseptins Have Overlapping Structural Features but Target Specific Microorganisms
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